NURECON: A Novel Online System for Determining Nutrition Requirements Based on Microbial Composition

作     者：Hu, Zhao-Qi Hung, Yuan-Mao Chen, Li-Han Lai, Liang-Chuan Pan, Min-Hsiung Chuang, Eric Y. Tsai, Mong-Hsun 

作者机构：National Taiwan University Institute of Biotechnology Graduate Institute of Biomedical Electronics and Bioinformatics Taipei10617 Taiwan National Taiwan University Graduate Institute of Biomedical Electronics and Bioinformatics Taipei10617 Taiwan National Taiwan University Institute of Fisheries Science Department of Life Science Taipei10617 Taiwan National Taiwan University Graduate Institute of Physiology College of Medicine and Bioinformatics and Biostatistics Core Center of Genomic and Precision Medicine Taipei10617 Taiwan National Taiwan University Institute of Food Sciences and Technology Taipei10617 Taiwan National Taiwan University Grad. Inst. of Biomedical Electronics and Bioinformatics and Bioinformatics and Biostatistics Core Center of Genomic and Precision Medicine Taipei10617 Taiwan Industrial Technology Research Institute Biomedical Technology and Device Research Laboratories Hsinchu310401 Taiwan National Taiwan University Institute of Biotechnology Taipei10617 Taiwan 

出 版 物：《IEEE/ACM Transactions on Computational Biology and Bioinformatics》 (IEEE/ACM Trans. Comput. BioL. Bioinf.)

年 卷 期：2024年第21卷第2期

页      面：254-264页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 0808[工学-电气工程] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 0835[工学-软件工程] 0836[工学-生物工程] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：Research and Development Center for Medical Devices, National Taiwan University Center of Genomic and Precision Medicine, National Taiwan University Center of Biotechnology, National Taiwan University, Taiwan National Taiwan University 

主　　题：Enzymes 

摘      要：Dietary habits have been proven to have an impact on the microbial composition and health of the human gut. Over the past decade, researchers have discovered that gut microbiota can use nutrients to produce metabolites that have major implications for human physiology. However, there is no comprehensive system that specifically focuses on identifying nutrient deficiencies based on gut microbiota, making it difficult to interpret and compare gut microbiome data in the literature. This study proposes an analytical platform, NURECON, that can predict nutrient deficiency information in individuals by comparing their metagenomic information to a reference baseline. NURECON integrates a next-generation bacterial 16S rRNA analytical pipeline (QIIME2), metabolic pathway prediction tools (PICRUSt2 and KEGG), and a food compound database (FooDB) to enable the identification of missing nutrients and provide personalized dietary suggestions. Metagenomic information from total number of 287 healthy subjects was used to establish baseline microbial composition and metabolic profiles. The uploaded data is analyzed and compared to the baseline for nutrient deficiency assessment. Visualization results include gut microbial composition, related enzymes, pathways, and nutrient abundance. NURECON is a user-friendly online platform that provides nutritional advice to support dietitians research or menu design. © 2004-2012 IEEE.