Biopolymer-based Sustainable Membrane for Skin Regeneration

作     者：Paramasivan, Mareeswari S, Shuvetha Priya K, Niranjan Balaji R, Varshini B, Yugesh Prasanna Gonmei, Monica Chingchuilin M K, Padmanabhan Mahajan, Roop L. P, Chithra Lekha 

作者机构：Healthcare Technologies Division Virginia Tech India Research and Education Forum Indian Institute of Technology Madras Research Park Chennai India Department of Biomedical Engineering SRM Institute of Science and Technology Ramapuram Chennai India Dr MGR Educational and Research Institute (Deemed to Be University) Chennai India Department of Mechanical Engineering Department of Materials Science and Engineering Virginia Tech Blacksburg USA 

出 版 物：《Materials Circular Economy》 

年 卷 期：2024年第6卷第1期

页      面：1-7页

摘      要：The primary objective of this study is to develop a membrane designed to expedite the healing process of burns and wounds. In our approach, we use Bacterial nanocellulose (BNC) cultivated from a kombucha tea culture, along with gelatin to create a sustainable wound-healing membrane. From the FTIR, the functional groups of both the BNC and gelatine in the membrane were apparent. The hydrophilic nature of the membrane indicated by its contact angle of 78.4 ± 3.4° promotes skin regeneration, by facilitating cell spreading, attachment, and tissue growth. Studies on the antibacterial activity of the generated membrane have shown that it successfully inhibits the growth of bacterial species such as Staphylococcus aureus and E. coli. The BNCG membrane demonstrates over 90% biocompatibility in MTT assay results validating its safe use in skin regeneration post third-degree burns. The formulated BNCG membrane shows a 95% closure rate in the L929 cell line, outperforming the control.