Green-Friendly Synthesis of 1,3,5-Triazine Derivatives Using a Sonochemical Protocol

作     者：Kulaga, Damian Drabczyk, Anna K. Zaręba, Przemyslaw Jaśkowska, Jolanta Chrzan, Julia Greber, Katarzyna Ewa Ciura, Krzesimir Plażuk, Damian Wielgus, Ewelina 

作者机构：Department of Organic Chemistry and Technology Faculty of Chemical Engineering and Technology Cracow University of Technology 24 Warszawska Street Cracow31-155 Poland Department of Chemical Technology and Environmental Analytics Faculty of Chemical Engineering and Technology Cracow University of Technology 24 Warszawska Street Cracow31-155 Poland Department of Physical Chemistry Faculty of Chemistry Medical University of Gdańsk 63 Gen. Hallera Alley Gdańsk80-416 Poland Laboratory of Environmental Chemoinformatics Faculty of Chemistry Medical University of Gdańsk 63 Wita Stwosza Street Gdańsk80-308 Poland University of Lodz Faculty of Chemistry Department of Organic Chemistry Laboratory of Molecular Spectroscopy 12 Tamka Street Lódź91-403 Poland Centre of Molecular and Macromolecular Studies Polish Academy of Science 112 Sienkiewicza Street Lódź90-363 Poland 

出 版 物：《SSRN》 

年 卷 期：2024年

核心收录：

主　　题：Sustainable chemistry 

摘      要：1,3,5-triazine derivatives are useful compounds with potential applications in various branches of chemical industry, including pharmaceutical chemistry, cosmetic chemistry, photochemistry, and organic chemistry. Due to the growing environmental requirements on conducting efficient, economical, and safe syntheses, development of new methods for synthesizing organic compounds is highly desirable. In this publication, we present a protocol for the synthesis of 1,3,5-triazine derivatives using a sonochemical approach. In as little as 5 minutes, it is possible to obtain most of the investigated compounds with a yield of over 75%. An undeniable advantage of this method, besides its short time, is the use of water as the solvent. Furthermore, we provide examples that the sonochemical method may be more versatile than the competing microwave method. Analysis conducted using the DOZNTM 2.0 tool revealed that in terms of the 12 principles of green chemistry, the developed sonochemical method is 13 times greener than the classical one. Additionally, it has been demonstrated that the investigated molecules are attractive for their application as drug-like compounds. © 2024, The Authors. All rights reserved.