AIE-based fluorescent sensing of ciprofloxacin using non-fluorescent 2D silver dimolybdate nanosheets: The synergistic sensor method (SGSM) to switch on non-fluorescent 2D nanosheets into an effective fluorescent biosensor

作     者：Rana, Priyanka Dabur, Deepak Wu, Hui-Fen 

作者机构：Department of Chemistry National Sun Yat-Sen University Kaohsiung 70 Lien-Hai Road Kaohsiung80424 Taiwan International PhD Program for Science National Sun Yat-Sen University Kaohsiung80424 Taiwan School of Pharmacy College of Pharmacy Kaohsiung Medical University Kaohsiung807 Taiwan Institute of Medical Science and Technology National Sun Yat-Sen University Kaohsiung80424 Taiwan School of Medicine College of Medicine National Sun Yat-Sen University Kaohsiung80424 Taiwan Institute of Precision Medicine National Sun Yat-Sen University Kaohsiung80424 Taiwan Institute of BioPharmaceutical Science National Sun Yat-Sen University Kaohsiung80424 Taiwan 

出 版 物：《Materials Today Chemistry》 (Mater. Today Chem.)

年 卷 期：2024年第38卷

核心收录：

基　　金：We thank financial support from the National Science and Technology Council (NSTC) is greatly acknowledged for the grant number: NSTC 112-2113-M-110-015 

主　　题：Fluorescence 

摘      要：The development of an efficient method for detecting ciprofloxacin (CIP) is critical due to the potential for significant harm to humans, including the danger of severe liver damage and hematuria associated with increased levels of this drug. In this study, we offer a highly sensitive and highly selective method for fluorescence sensing of the antibiotic ciprofloxacin employing the properties of Aggregation-Induced Emission (AIE) with silver dimolybdate nanosheets (Ag2Mo2O7 NSs). Outstanding structural characteristics of the Ag2Mo2O7 NSs achieved using the hydrothermal method. By carefully controlling the aggregation of the Synergistic Sensor Method (SGSM), we are able to produce a very bright fluorescence response with the ciprofloxacin concentration range from 0 to 250 nM with a low detection limit of 1.1 nM. Quick and ultrasensitive detection has been achieved by the Synergistic effect (SGE) and AIE from the current approach. The SGSM has been shown to be a novel platform for human health monitoring and pharmaceutical quality control. With broad-ranging practical implications, the combination of AIE and silver dimolybdate nanosheets offers a platform for reliable and ciprofloxacin detection. We believe the SGSM is a role model paper for future nano-biosensor detection methods due to the synergistic effect resulting in the AIE and turn-on sensor approach for many non-fluorescent 2D nanosheets. This can open many new doors for the intensive development of 2D nanosheets for future fluorescent sensors without the need to produce fluorescence by the nanosheet itself. © 2024