Light-driven sextuple theranostics:nanomedicine involving second near-infrared AIE-active Ir(Ⅲ)complex for prominent cancer treatment

作     者：Xue Liu Jiangao Li Fei Zhang Dingyuan Yan Lei Wang Dong Wang Ben Zhong Tang 

作者机构：Center for AIE ResearchShenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Material Science and EngineeringShenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China School of Science and EngineeringShenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2024年第67卷第7期

页      面：2314-2324页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 0702[理学-物理学] 

基　　金：partially supported by the National Natural Science Foundation of China(52122317,22175120,22305049) the Science and Technology Foundation of Shenzhen City(JCYJ20190808153415062,RCYX20200714114525101,20220809130438001,JSGG20220606141800001,JCYJ20200109110608167) the Pearl River Talent Recruitment Program(2019QN01Y103) 

主　　题：aggregation-induced emission NIR-II emission cancer theranostics multimodal diagnosis imaging multimodal therapy 

摘      要：Light-driven cancer theranostics has shown inexhaustible and vigorous vitality by virtue of its high efficacy,prominent controllability and *** of an all-round theranostic material simultaneously affording both multimodal diagnosis imaging and synergistic phototherapy would be an appealing yet significantly challenging ***,a novel nanomedicine Ir@PPEG-MeEPO was ingeniously constructed by integrating beforehand1O2-charged amphiphilic polymer and well-tailored Ir(Ⅲ)complex IrDPTP,which was featured by second near-infrared(NIR-Ⅱ)aggregation-induced emission(AIE)tendency,efficient reactive oxygen species(ROS)generation,good photothermal conversion efficiency and high-performance hydrogen gas *** the best of our knowledge,IrDPTP held the longest emission wavelength among all reported AIE Ir(Ⅲ)***,Ir@PPEG-MeEPO was capable of controllably releasing ROS via triggered photothermal effect upon NIR irradiation,making it well-adapted to hypoxic environment of *** distinctive characteristics of Ir@PPEG-MeEPO endowed it with unprecedented performance on sextuple theranostics comprised of NIR-Ⅱfluorescence-photoacoustic-photothermal trimodal imaging and photodynamic-photothermal-hydrogen trimodal therapy,witnessed by the precise tumor diagnosis and complete tumor *** study would open up new perspectives for the exploration of superior nanomedicine for practical cancer theranostics.