Structure-Functional Activity of Pyrone Derivatives for Inhibition of Barnacle Settlement and Biofilm Formation

作     者：Khan, Mo Aqib Raza Wang, Bo-Wei Lin, Hsiu-Chin Yang, Yu-Liang Liaw, Chih-Chuang 

作者机构：Department of Marine Biotechnology and Resources National Sun Yat-Sen University Kaohsiung80424 Taiwan Doctoral Degree Program in Marine Biotechnology National Sun Yat-Sen University Kaohsiung80424 Taiwan Agricultural Biotechnology Research Center Academia Sinica Taipei115 Taiwan Biotechnology Center in Southern Taiwan Academia Sinica Tainan711 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung807 Taiwan Graduate Institute of Pharmacognosy Taipei Medical University Taipei110 Taiwan 

出 版 物：《Marine Biotechnology》 (Mar. Biotechnol.)

年 卷 期：2024年第26卷第5期

页      面：1000-1008页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 071010[理学-生物化学与分子生物学] 07[理学] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：For CCL  this research work was supported in part by a Ministry of Science and Technology grant (MOST108-2320-B-110-006-MY3) and a grant from the National Sun Yat-sen University-Kaohsiung Medical University Joint Research Project (NSYSU-KMU 111-I06) to CCL.The authors appreciate Mr. Guo-Kai Hong\u2019s assistance on the barnacle cyprids screening assay. This manuscript was edited by Wallace Academic Editing 

主　　题：Bacteria 

摘      要：Naturally occurring 6-pentyl-2H-pyran-2-one and its synthetic analogues greatly inhibit the settlement of Amphibalanus amphitrite cyprids and the growth and biofilm formation of marine bacteria. To optimize the antifouling activities of pyrone derivatives, this study designed pyrone analogues by modifying functional groups, such as the benzyl group, cyclopentane, and halides, substituted on both sides of a pyrone. The antifouling effects of the synthesized pyrone derivatives were subsequently evaluated against five marine biofilm–forming bacteria, Loktanella hongkongensis, Staphylococcus cohnii, S. saprophyticus, Photobacterium angustum, and Alteromonas macleodii, along with barnacle cyprids of Amphibalanus amphitrite. Substituting nonpolar parts—such as the aliphatic, cyclopentyl, or phenyl moieties on C-5 or the furan moieties on C-3—not only increased antibacterial activity and inhibited biofilm formation but also inhibited barnacle cyprid settlement when compared to 6-pentyl-2H-pyran-2-one. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.