Pyrrole and pyrrolidine analogs:The promising scaffold in discovery of pesticides

作     者：Anjing Liao Wei Sun Yaming Liu Han Yan Zhi Xia Jian Wu Anjing Liao;Wei Sun;Yaming Liu;Han Yan;Zhi Xia;Jian Wu

作者机构：State Key Laboratory of Green PesticideKey Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityHuaxi DistrictGuiyang 550025China College of Chemistry and Chemical EngineeringGuizhou University of Engineering ScienceBijie 551700China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报(英文版))

年 卷 期：2025年第36卷第3期

页      面：113-124页

核心收录：

学科分类：090403[农学-农药学(可授农学、理学学位）] 09[农学] 0904[农学-植物保护] 

基　　金：financial support from the National Natural Science Foundation of China(No.32072445) the Science and Technology Plan Project of Guizhou Province(Qiankehezhichengthe general 083) the Program of Introducing Talents to Chinese Universities(No.D20023) the Central Government Guides Local Science and Technology Development Fund Projects(Qiankehezhongyindi(2023)001) Key Agricultural Technology R&D Projects of the Xinjiang Production and Construction Corps(NYHXGG,2023AA602) the Frontiers Science Centre for Asymmetric Synthesis and Medicinal Molecules,Department of Education,Guizhou Province[Qianjiaohe KY(2020)004] the specific research fund of The Innovation Platform for Academicians of Hainan Province(No.SQ2020PTZ0009) 

主　　题：Pyrrole Pyrrolidone Agrochemicals Biological activity Structure-activity relationship 

摘      要：Pyrrole is a heterocycle with four carbon atoms and a nitrogen atom,which is extensively used in the pesticide and pharmaceutical *** addition,it has a series of analogs such as pyrrolidine,pyrroline,and *** containing pyrrole and its analogs have been formally marketed as fungicides,including fenpiclonil,fludioxonil,the insecticide chlorfenapyr,and the herbicide *** this paper,we analyze the structure-activity relationships(SARs)of pesticides containing these *** summarize the characteristics possessed by the most highly active pyrrole and its analogs and provide an overview of research on pyrrole compounds with insecticidal,antimicrobial,herbicidal,and antiviral properties in the past 20 *** is hoped to provide ideas for the development and design of this type compounds in pesticides and to assist researchers in this area.