In situ transcriptomic analysis of spermatocytes in non-obstructive azoospermia reveals senescence-like states in arrested spermatocytes

作     者：Zhongqin Wu Xiaolong Wu Zeqian Xu Yixin Liu Ziyi Zhu Xinhui Li Daniel M. Czajkowsky Fei Sun Yan Guo Zhifeng Shao 

作者机构：State Key Laboratory of Systems Medicine for CancerSchool of Biomedical Engineering and Bio-ID CenterShanghai Jiao Tong UniversityShanghai 200240China Department of Urology and AndrologySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang 310016China 

出 版 物：《Genes & Diseases》 (基因与疾病(英文))

年 卷 期：2025年第12卷第1期

页      面：29-32页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81972909,31971151) the National Key Research and Development Program of China(No.2021YFC2700200) the Bio-ID Center at SJTU,and the K.C.Wong Education Foundation(H.K.) 

主　　题：obstructive azoospermia arrest 

摘      要：Germ cell arrest is one kind of important disease in nonobstructive azoospermia(NOA)including spermatogonia arrest,spermatocyte arrest,and round spermatid arrest.1 There is an urgent need to explore the molecular mechanisms underlying germ cell arrest,which are essentially unknown and could provide not only a promising approach for therapy but also novel possibilities for developing male contraceptives.