Capillaritis associated with interferon-alfa treatment of chronic hepatitis C infection

作     者：Gupta, G Holmes, SC Spence, E Mills, PR 

作者机构：Univ Glasgow Western Infirm Dept Dermatol Glasgow G11 6NT Lanark Scotland Univ Glasgow Western Infirm Dept Gastroenterol Glasgow G11 6NT Lanark Scotland 

出 版 物：《JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY》 (美国皮肤病学会志)

年 卷 期：2000年第43卷第5期

页      面：937-938页

核心收录：

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

基　　金：American Academy of Dermatology  AAD 

主　　题：抗病毒药/副作用 抗病毒药/治疗应用 丙型肝炎 慢性/药物疗法 组织细胞/病理学 干扰素α/副作用 干扰素α/治疗应用 淋巴细胞/病理学 皮肤/病理学 皮肤疾病 血管性/化学诱导 皮肤疾病 血管性/病理学 血管炎/化学诱导 血管炎/病理学 成年人 人类 男(雄)性 

摘      要：We report the case of a 36-year-old man who was referred with an asymptomatic eruption that started on both lower legs. This started shortly after being commenced on interferon-alfa for chronic hepatitis secondary to hepatitis C. Clinically, the eruption was consistent with a capillaritis (pigmented purpuric dermatosis). Histology confirmed this to be lymphocytic vasculitis. Lymphocytic vasculitis is frequently identified in the salivary glands of patients who are hepatitis C positive. Although leukocytoclastic vasculitis confined to the skin is frequently reported with hepatitis C, lymphocytic vasculitis is rarely reported. We consider that the lymphocytic vasculitis in our patient occurred as a result of interferon-alfa treatment because of the strong temporal relationship between the onset of the skin eruption and drug therapy.