A novel plasma p-tau181 assay as a specific biomarker of tau pathology in Alzheimer’s disease

作     者：Kenji Tagai Harutsugu Tatebe Sayo Matsuura Zhang Hong Naomi Kokubo Kiwamu Matsuoka Hironobu Endo Asaka Oyama Kosei Hirata Hitoshi Shinotoh Yuko Kataoka Hideki Matsumoto Masaki Oya Shin Kurose Keisuke Takahata Masanori Ichihashi Manabu Kubota Chie Seki Hitoshi Shimada Yuhei Takado Kazunori Kawamura Ming-Rong Zhang Yoshiyuki Soeda Akihiko Takashima Makoto Higuchi Takahiko Tokuda 

作者机构：Advanced Neuroimaging CenterInstitute for Quantum Medical ScienceNational Institutes for Quantum Science and Technology(QST)4-9-1 AnagawaInage-kuChiba-shiChiba 263-8555Japan Department of PsychiatryThe Jikei University of MedicineTokyo 105-8461Japan Department of Oral and Maxillofacial RadiologyTokyo Dental CollegeTokyo 101-0061Japan Department of PsychiatryKeio University School of MedicineTokyo 160-0016Japan Department of Functional Neurology and NeurosurgeryCenter for Integrated Human Brain ScienceBrain Research InstituteNiigata UniversityNiigata 951-8585Japan Laboratory for Alzheimer’s DiseaseDepartment of Life ScienceFaculty of ScienceGakushuin UniversityTokyo 171-8588Japan 

出 版 物：《Translational Neurodegeneration》 (转化神经变性病(英文))

年 卷 期：2024年第13卷第1期

页      面：457-461页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：supported in part by AMED under Grant Numbers JP18dm0207018,JP19dm0207072,JP18dk0207026,JP19dk0207049,21wm0425015,21dm0307003,22dk0207055 MEXT KAKENHI under Grant Numbers JP16H05324 and JP18K07543 JST under Grant Numbers JPMJCR1652 and JPMJMS2024 the Kao Research Council for the Study of Healthcare Science,Biogen Idec Inc.and APRINOIA Therapeutics 

主　　题：tau Alzheimer Aβ 

摘      要：Main text Alzheimer’s disease(AD),the most prevalent form of dementia,is characterized by deposits of two abnormal proteins,namely amyloid-β(Aβ)and tau,in the *** is growing evidence for the clinical significance of plasma phosphorylated tau(p-tau)assays in detecting AD pathology[1,2],similar to CSF and positron emission tomography(PET)*** available immunoassays for plasma p-tau detect C-terminally truncated p-tau containing the N-terminus to the mid-domain(N-p-tau)[2].