PRIME: Phase Reversed Interleaved Multi-Echo acquisition enables highly accelerated distortion-free diffusion MRI

作     者：Jun, Yohan Liu, Qiang Gong, Ting Cho, Jaejin Fujita, Shohei Yong, Xingwang Huang, Susie Y. Ning, Lipeng Yendiki, Anastasia Rathi, Yogesh Bilgic, Berkin 

作者机构：Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital BostonMA United States Department of Radiology Harvard Medical School BostonMA United States Brigham and Women’s Hospital Harvard Medical School BostonMA United States Department of Electrical and Computer Engineering Northeastern University BostonMA United States Department of Artificial Intelligence and Robotics Sejong University Seoul Korea Republic of Zhejiang University Hangzhou China Harvard/MIT Health Sciences and Technology CambridgeMA United States Department of Psychiatry Brigham and Women’s Hospital BostonMA United States Department of Radiology Brigham and Women’s Hospital BostonMA United States 

出 版 物：《arXiv》 (arXiv)

年 卷 期：2024年

核心收录：

主　　题：Nuclear magnetic resonance 

摘      要：Purpose: To develop and evaluate a new pulse sequence for highly accelerated distortion-free diffusion MRI (dMRI) by inserting an additional echo without prolonging TR, when generalized slice dithered enhanced resolution (gSlider) radiofrequency encoding is used for volumetric acquisition. Methods: A phase-reversed interleaved multi-echo acquisition (PRIME) was developed for rapid, high-resolution, and distortion-free dMRI, which includes two echoes where the first echo is for target diffusion-weighted imaging (DWI) acquisition with high-resolution and the second echo is acquired with either 1) lower-resolution for high-fidelity field map estimation, or 2) matching resolution to enable efficient diffusion relaxometry acquisitions. The sequence was evaluated on in vivo data acquired from healthy volunteers on clinical and Connectome 2.0 scanners. Results: In vivo experiments demonstrated that 1) high in-plane acceleration (Rin-plane of 5-fold with 2D partial Fourier) was achieved using the high-fidelity field maps estimated from the second echo, which was made at a lower resolution/acceleration to increase its SNR while matching the effective echo spacing of the first readout, 2) high-resolution diffusion relaxometry parameters were estimated from dual-echo PRIME data using a white matter model of multi-TE spherical mean technique (MTE-SMT), and 3) high-fidelity mesoscale DWI at 550 μm isotropic resolution could be obtained in vivo by capitalizing on the high-performance gradients of the Connectome 2.0 scanner. Conclusion: The proposed PRIME sequence enabled highly accelerated, high-resolution, and distortion-free dMRI using an additional echo without prolonging scan time when gSlider encoding is utilized. Copyright © 2024, The Authors. All rights reserved.