Metabolic and epigenetic regulation of macrophage polarization in atherosclerosis: Molecular mechanisms and targeted therapies

作     者：Yang, Pinglian Rong, Xiaoling Gao, Zhechang Wang, Jiaojiao Liu, Zhiping 

作者机构：Jinan Univ Coll Pharm Int Cooperat Lab Tradit Chinese Med Modernizat & I Chinese Minist Educ MOEState Key Lab Bioact Mol & Guangzhou 510632 Peoples R China Nanjing Univ Chinese Med Sch Pharm Nanjing 210023 Peoples R China Guangdong Med Univ Key Lab Big Data Min & Precis Drug Design Guangdon Key Lab Comp Aided Drug Design Dongguan City Key Lab Res & Dev Nat Drugs Guangdong ProvSch Pha Dongguan 523808 Peoples R China 

出 版 物：《PHARMACOLOGICAL RESEARCH》 (Pharmacol. Res.)

年 卷 期：2025年第212卷

页      面：107588页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：National Natural Science Foundation of China [82270500, 82203304, 81870324] Guangdong Basic and Applied Basic Research Foundation [2024B1515020113] 

主　　题：Macrophage polarization Atherosclerosis Epigenetic Metabolism Noncoding RNA Therapies 

摘      要：Atherosclerosis, a multifactorial progressive inflammatory disease, is the common pathology underlying cardiovascular and cerebrovascular diseases. The macrophage plasticity is involved in the pathogenesis of atherosclerosis. With the advance of metabolomics and epigenetics, metabolites/metabolic and epigenetic modification such as DNA methylation, histone modification and noncoding RNA, play a crucial role in macrophage polarization and the progression of atherosclerosis. Herein, we provide a comprehensive review of the essential role of metabolic and epigenetic regulation, as well as the crosstalk between the two in regulating macrophage polarization in atherosclerosis. We also highlight the potential therapeutic strategies of regulating macrophage polarization via epigenetic and metabolic modifications for atherosclerosis, and offer recommendations to advance our knowledge of the roles of metabolic-epigenetic crosstalk in macrophage polarization in the context of atherosclerosis. Fundamental studies that elucidate the mechanisms by which metabolic and epigenetic regulation of macrophage polarization influence atherosclerosis will pave the way for novel therapeutic approaches.