Reply to:comment on"Early cancer detection by serum biomolecular fingerprinting spectroscopy with machine learning"

作     者：Shilian Dong Dong He Qian Zhang Chaoning Huang Zhiheng Hu Chenyang Zhang Lei Nie Kun Wang Wei Luo Jing Yu Bin Tian Wei Wu Xu Chen Fubing Wang Jing Hu Xiangheng Xiao Shilian Dong;Dong He;Qian Zhang;Chaoning Huang;Zhiheng Hu;Chenyang Zhang;Lei Nie;Kun Wang;Wei Luo;Jing Yu;Bin Tian;Wei Wu;Xu Chen;Fubing Wang;Jing Hu;Xiangheng Xiao

作者机构：School of Physics and TechnologyNational Demonstration Center for Experimental Physics EducationWuhan UniversityWuhan 430072China Department of Laboratory MedicineZhongnan Hospital of Wuhan UniversityWuhan 430071China School of Computer ScienceWuhan UniversityWuhan 430072China Department of Hepatobiliary Pancreatic SurgeryHubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079China Department of Clinical LaboratoryTianjin Medical University General HospitalTianjin 300052China Department of Blood TransfusionWuhan Hospital of Traditional Chinese and Western MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Laboratory of Printable Functional Materials and Printed ElectronicsResearch Center for Graphic CommunicationPrinting and PackagingWuhan UniversityWuhan 430072China Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical GeneticsDepartment of Laboratory MedicineSichuan Academy of Medical Sciences & Sichuan Provincial People's HospitalUniversity of Electronic Science and TechnologyChengdu 611731China School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China 

出 版 物：《光：科学与应用（英文版）》 (Light：Science & Applications)

年 卷 期：2025年第14卷第2期

页      面：566-578页

核心收录：

学科分类：070207[理学-光学] 07[理学] 08[工学] 0803[工学-光学工程] 0702[理学-物理学] 

主　　题：fingerprinting learning detection cancer with biomolecular comment early machine reply 

摘      要：Dear Editor, In the accompanying Comment,Bratchenko et *** two concerns about the spectral data analysis pipeline employed for the Surface-enhanced Raman scattering and Artificial Intelligence for Cancer Screening(SERS-AICS)technique in our original paper1:(1)inappropriate accu-racy presentation and(2)the use of a single data split for model *** a promising technique for molecular fingerprinting,SERS-based early cancer detection approaches using biofluids and liquid biopsy are typically evaluated based strictly on their accuracy and reliability2-8.