EVALUATION OF SYRINGIC ACID-LOADED BORONIC ACID FUNCTIONALIZED MESOPOROUS SILICA PROPERTIES

作     者：Ionita, Simona Deaconu, Mihaela Irimescu, Ionela Nicoleta Popescu, Roxana Cristina Mihailescu, Mona Sandu, Ana Maria Prundeanu, Mioara Savu, Diana Iulia Berger, Daniela 

作者机构：Department of Inorganic Chemistry Physical-Chemistry & Electrochemistry National University of Science and Technology POLITEHNICA of Bucharest Romania CAMPUS Research Centre National University of Science and Technology POLITEHNICA of Bucharest Romania Applied Sciences Doctoral School National University of Science and Technology POLITEHNICA of Bucharest Tehnoplus Medical SRL Bucharest Romania Department of Life and Environmental Sciences "Horia Hulubei" National Institute for Research and Development in Physics and Nuclear Engineering Magurele Romania Department of Bioengineering and Biotechnology National University of Science and Technology POLITEHNICA of Bucharest Romania Department of Physics National University of Science and Technology POLITEHNICA of Bucharest Romania 

出 版 物：《UPB Scientific Bulletin, Series B: Chemistry and Materials Science》 (UPB Sci Bull Ser B)

年 卷 期：2024年第86卷第4期

页      面：5-18页

核心收录：

基　　金：This study was funded by UEFISCDI National Funding Agency (Romania) through the project no 576PED/2022 

主　　题：Mesopores 

摘      要：Nanotechnology addresses a current issue in cancer treatment, the non-specificity of cytotoxic agents associated with severe side effects. Mesoporous silica-based systems emerged as promising drug delivery vehicles that can be modified to target tumoral cells in order to achieve a better therapeutic effect. Herein, MCM-41 silica was functionalized with a boronic acid derivative, as a targeting agent towards breast cancer cells, and loaded with syringic acid, a phenolic acid with a reported antitumoral potential. The resulting system’s cytotoxicity and internalization into cells were evaluated on breast cancer cells and compared to human fibroblasts. © 2024, Politechnica University of Bucharest. All rights reserved.