Highly oxygenated cyclohexenes from the leaves of Uvaria grandiflora Roxb. ex Hornem and their cytotoxic and α-glucosidase inhibitory activities

作     者：Suthiphasilp, Virayu Betangah, Moses Egoh Teerapongpisan, Passakorn Rujanapun, Narawadee Chaiyosang, Boonyanoot Tontapha, Sarawut Kumboonma, Pakit Patrick, Brian O. Andersen, Raymond J. Charoensup, Rawiwan Duangyod, Thidarat Promnart, Phunrawie Maneerat, Tharakorn Laphookhieo, Surat 

作者机构：Department of Industrial Technology and Innovation Management Faculty of Science and Technology Pathumwan Institute of Technology Bangkok 10330 Thailand Center of Chemical Innovation for Sustainability (CIS) and School of Science Mae Fah Luang University Chiang Rai 57100 Thailand Futuristic Science Research Center School of Science Walailak University Nakhon Si Thammarat 80160 Thailand Center of Excellence for Advanced Research in Future-Oriented Sciences (CEAR-FOS) Walailak University Nakhon Si Thammarat 80160 Thailand Medicinal Plants Innovation Center of Mae Fah Luang University Chiang Rai 57100 Thailand Natural Products Research Unit Department of Chemistry and Center of Excellence for Innovation in Chemistry Faculty of Science Khon Kaen University Khon Kaen 40002 Thailand Institute of Nanomaterials Research and Innovation for Energy Khon Kaen University Khon Kaen 40002 Thailand Department of Applied Chemistry Faculty of Science and Liberal Arts Rajamangala University of Technology Isan Nakhon Ratchasima 30000 Thailand Departments of Chemistry and Earth Ocean & Atmospheric Sciences University of British Columbia 2036 Main Mall Vancouver V6T 1Z1 BC Canada School of Integrative Medicine Mae Fah Luang University Chiang Rai 57100 Thailand School of Science Mae Fah Luang University Chiang Rai 57100 Thailand 

出 版 物：《Heliyon》 (Heliyon)

年 卷 期：2025年第11卷第1期

页      面：e41326页

基　　金：Thailand Science Research and Innovation, TSRI National Science, Research, and Innovation Fund University of British Columbia, UBC Mae Fah Luang University, MFU, (672A01030) Mae Fah Luang University, MFU National Research Council of Thailand, NRCT, (N42A650373) National Research Council of Thailand, NRCT 

主　　题：Annonaceae Cytotoxicity Highly oxygenated cyclohexenes Uvaria grandiflora α-Glucosidase inhibitory activity 

摘      要：Phytochemical investigation of the leaf extract of Uvaria grandiflora Roxb. ex Hornem led to the isolation and identification of two new highly oxygenated cyclohexenes, uvariagrandols A (1) and B (2), together with seven known compounds (3–9). Their structures were elucidated by spectroscopic methods as well as comparisons made from the literature. The (1S,2S,3R,6S) absolute configuration of uvariagrandols A and B was established by the comparison of the experimental and calculated electronic circular dichroism (ECD). (+)-Grandifloracin (9) displayed cytotoxicity against SW480 and K562 cell lines with IC50 values of 154.9 and 60.9 μM, respectively. 6-Methoxyzeylenol (5) had α-glucosidase inhibitory activity with the IC50 value of 34.1 μM. © 2024 The Authors