Garlic-derived nanoparticles inhibit tumor by activating tumor infiltrating γδT cells

作     者：Jialu Xu Jintao Huang Yue Yu Di Hu Yue Zhang Huaxing Dai Li You Fang Xu Jian Shen Chao Wang Jialu Xu;Jintao Huang;Yue Yu;Di Hu;Yue Zhang;Huaxing Dai;Li You;Fang Xu;Jian Shen;Chao Wang

作者机构：Department of Interventional RadiologyThe First Affiliated Hospital of Soochow UniversitySuzhou 215006China Institute of Functional Nano&Soft Materials(FUNSOM)Jiangsu Key Laboratory for Carbon-based Functional Materials and DevicesSoochow UniversitySuzhou 215123China 

出 版 物：《Nano Research》 (纳米研究(英文版))

年 卷 期：2025年第18卷第2期

页      面：586-593页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the National Key R&D Program of China(No.2022YFB3808100) the National Natural Science Foundation of China(No.32371476) 

主　　题：garlic-derived nanoparticles γδT cells tumor microenvironment antitumor effects 

摘      要：γδT cells have emerged as a promising target in tumor therapy,prompting the development of novel strategies to activate these cells directly within the tumor *** this study,we engineered uniformly sized spherical garlic-derived nanoparticles(GNPs)to stimulate tumor-infiltratingγδT *** intratumoral injection of GNPs,we demonstrated their ability to directly activate γδT cells,leading to potent antitumor *** approach resulted in significant inhibition of various subcutaneous tumors in ***,under computed tomography(CT)guidance,intratumoral injection of GNPs effectively suppressed the growth of orthotopic liver cancer in New Zealand white *** studies revealed that GNPs robustly activated γδT cells,promoting an inflammatory microenvironment within *** approach of using garlic-derived nanoparticles offers the advantages of simplicity in preparation and high yield,presenting a promising avenue for tumor therapy with potential for clinical translation.