Flower-like gap-enhanced Raman tags wrapped with polydopamine-functionalized MoS2 nanosheets for phototheranostic nanoplatform

作     者：Chen, Ming Zhao, Xing Wang, Bin Li, Da Xu, Xiaoxuan Liu, Hongliang Ai, Siwen Sun, Lu 

作者机构：Nankai Univ Inst Modern Opt Eye Inst Tianjin 300350 Peoples R China Nankai Univ Coll Artificial Intelligence Tianjin 300350 Peoples R China Tianjin Key Lab Microscale Opt Informat Sci & Tech Tianjin 300350 Peoples R China Chongqing Technol & Business Univ Sch Artificial Intelligence Chongqing 400067 Peoples R China 

出 版 物：《JOURNAL OF MATERIALS SCIENCE》 (J Mater Sci)

年 卷 期：2025年第60卷第4期

页      面：1873-1890页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：Key Technologies Research and Development Program of Anhui Province [19YFZCSY00250] Tianjin Key RD Program [NKYKD202204, NKYKK202209] Nankai University Eye Institute 

主　　题：Nanosheets 

摘      要：Phototheranostic nanoplatforms that perform simultaneous optical imaging and phototherapy through light activation are considered a promising approach for early diagnosis, surgical guidance, and precision treatment of cancer. In this work, we develop a novel flower-like gap-enhanced Raman tags (for brief, PMF-GERTs) wrapped with polydopamine (PDA)-functionalized molybdenum disulfide (MoS2) nanosheets. In PMF-GERTs, 4,4 -biphenyldithiol (BPDT) Raman reporter molecules are embedded in the nanogap between the gold core and the flower-like shell, and PDA-functionalized MoS2 nanosheets (PDA/MoS2) were wrapped on the surface of the flower-shaped shell. Photothermal and photodynamic experiments show that PDA/MoS2 nanosheets significantly improve the photothermal performance and photodynamic response ability of Raman tags in the NIR-II region. Under the irradiation of 1064 nm laser (1 W/cm2), the PMF-GERTs solution can heat up to 66 degrees C within 300 s, and the photothermal conversion efficiency reaches 43.6%. Moreover, PMF-GERT also has excellent photothermal stability and photodynamic properties and can perform effective phototherapy on 4T1 tumor cells. In Raman spectra and mapping imaging experiments, PMF-GERTs have strong enhanced Raman signals, lower detection thresholds and long-time physiological environment stability (72 h). In addition, PMF-GETRs also have excellent performance in simulating biological tissues and biological Raman mapping imaging. This novel Raman tag is expected to be used to develop phototheranostic nanoplatform that integrates Raman imaging diagnosis and photothermal and photodynamic therapy.