Impact of Parent-Reported Antibiotic Allergies on Pediatric Antimicrobial Stewardship Programs

作     者：Arnold, Annabelle Coventry, Linda L. Foster, Mandie J. Trevenen, Michelle McKinnon, Elizabeth J. MacLindon, Sarah Goff, Zoy H. Blyth, Christopher C. Lucas, Michaela 

作者机构：Immunology Department Perth Children's Hospital Perth WA Australia School of Nursing and Midwifery Edith Cowan University Perth WA Australia Centre for Nursing Research Sir Charles Gairdner Hospital Perth WA Australia Auckland University of Technology School of Clinical Sciences Auckland New Zealand Centre for Applied Statistics School of Physics Mathematics and Computing University of Western Australia Perth WA Australia Telethon Kids Institute Perth WA Australia Infectious Diseases Department Perth Children's Hospital Perth WA Australia Pharmacy Department Perth Children's Hospital Perth WA Australia Medical School University of Western Australia Perth WA Australia Department of Microbiology PathWest Laboratory Medicine WA Perth WA Australia Immunology Department PathWest Laboratory Medicine WA Perth WA Australia Immunology Department Sir Charles Gairdner Hospital Perth WA Australia 

出 版 物：《Journal of Allergy and Clinical Immunology: In Practice》 (J. Allergy Clin. Immunol. Pract.)

年 卷 期：2025年第13卷第5期

页      面：1083-1093.e12页

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Antibiotic allergy Antimicrobial stewardship Drug allergy Pediatrics 

摘      要：Background: Antimicrobial stewardship (AMS) is crucial for optimizing antimicrobial use and restraining emergence of antimicrobial resistance. The overall increase in reported antibiotic allergies in children can pose a significant barrier to AMS, but its impact on clinical AMS care in children has not been addressed. Objective: To compare the clinical outcomes for children with a reported antibiotic allergy label (AAL) with those with no AAL reviewed by AMS. Methods: A retrospective cohort study was conducted in a pediatric tertiary hospital, capturing 1590 inpatient admissions reviewed under the AMS between 2017 and 2019. Logistic, log-binomial, and Cox regression analyses were undertaken. Data collected included a documented AAL, antibiotic prescriptions, principal diagnosis, admitting specialty, hospital length of stay, intensive care admissions, and hospital readmissions. Results: All 1590 pediatric patients were prescribed at least 1 antibiotic. AALs were recorded in 6.6% of patients;majority were β-lactam (82%), mostly penicillins (71%). AALs increased with age (P .001);no gender effect was seen. Patients with AALs received more quinolones (P .001), lincosamides (P = .001), aminoglycosides (P .001), and metronidazole (P = .015) than patients with no AALs. In contrast, children with no AAL received more penicillin (P .001). Children with any AAL had marginally longer hospital length of stay, median (interquartile range [IQR]) 7.0 (4.0, 15.0) days, than those without, median (IQR) 5.0 (3.75, 11.0) days, P = .027. Conclusion: This study is the first to show how AALs impact clinical outcomes in children under an AMS program. With recent advances in delabeling, early intervention in cases of AAL should target children under AMS services who are in immediate need of optimal antibiotic management. © 2025