Four Pairs of Meroterpenoid Enantiomers with Coumarin- and Chromone-Monoterpene Skeletons from Gerbera Piloselloides and Their Bioactive Activities

作     者：Zou, Zhong-Mei Chen, Shi-Lin Zhao, Chen-Xu Gao, Ha Zhang, Tao 

作者机构：State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing100193 China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education Beijing100193 China 

出 版 物：《SSRN》 

年 卷 期：2024年

核心收录：

主　　题：Enantiomers 

摘      要：Phytochemical investigations of the extracts from the whole plant of Gerbera piloselloides resulted in the isolation and identification of four pairs of previously unreported meroterpenoid enantiomers with coumarin- and chromone-monoterpene skeletons (1a/1b–4a/4b), including two pairs of 5-methylcoumarin monoterpenes and two pairs of 5-methylchromone monoterpenes. The structures and absolute configurations of these compounds were definitively determined through NMR and MS data, electronic circular dichroism (ECD) data, and X-ray diffraction analysis. Structurally, compounds 1–4 feature 5-methylphenylpropanoid-substituted monoterpene frameworks. All compounds were evaluated for neuroprotective activity and cytotoxicity against the human cancer cell line SGC-7901 in vitro. Compounds 1, 1a, and 1b exhibited inhibitory effects with IC50 values ranging from 12.07 to 12.44 μM against SGC-7901. Furthermore, the hypothetical biogenetic pathways for these compounds were discussed. © 2024, The Authors. All rights reserved.