极早产儿和极低出生体重儿动脉导管未闭危险因素分析

作     者：张格 程秋阳 孟哲萱 丁艳洁 

作者机构：青岛大学青岛医学院附属烟台毓璜顶医院新生儿科山东 烟台 

出 版 物：《临床医学进展》 (Advances in Clinical Medicine)

年 卷 期：2025年第15卷第1期

页      面：400-407页

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：极早产儿 极低出生体重儿 动脉导管未闭 危险因素 

摘      要：目的:研究极早产儿和极低出生体重儿动脉导管未闭的危险因素。方法:回顾性收集青岛大学附属烟台毓璜顶医院2019年1月~2022年12月收治的胎龄 Objective: To study the risk factors of patent ductus arteriosus in very preterm and very low birth weight infants. Methods: A retrospective collection of clinical data was conducted on very preterm infants with gestational age 32 weeks or very low birth weight infants weighing 1500 g who were admitted to Yantai Yuhuangding Hospital affiliated with Qingdao University from January 2019 to December 2022. The subjects were divided into two groups based on the ultrasound in the first 5 - 7 days after birth echocardiographic findings: the PDA group (263 cases) and the non-PDA (nPDA) group (262 cases). Univariate and binary logistic regression analyses were used to explore the risk factors of patent ductus arteriosus in very preterm and very low birth weight infants. Results: The results of univariate analyses showed that the occurrence of PDA was associated with premature rupture of membranes, cesarean section, gestational age, birth weight, maternal comorbidities with diabetes mellitus, prenatal use of glucocorticoids and antibiotics, asphyxia, respiratory distress syndrome, respiratory support, endotracheal intubation, caffeine and lung surfactant application, leukocyte counts, 1-minute Apgar score and 5-minute Apgar score (P 0.05). Binary logistic regression analysis showed that premature rupture of membranes, antepartum use of dexamethasone, and elevated white blood cell counts are independent protective factors for PDA, and tracheal intubation at birth was an independent risk factor (P 0.05). Conclusion: Identifying the risk factors for arterial ductus arteriosus in very preterm and very low birth weight infants as early as possible can help achieve individualized management of this condition.