IMMUNOHISTOCHEMICAL ANALYSIS OF THE ONTOGENY OF NEUROPEPTIDE-Y IMMUNOREACTIVE NEURONS IN FETAL-RAT BRAIN

作     者：FOSTER, GA SCHULTZBERG, M 

作者机构：Department of Histology Karolinska Institutet Stockholm Sweden. 

出 版 物：《INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE》 (国际发育神经科学杂志)

年 卷 期：1984年第2卷第4期

页      面：387-407页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

主　　题：Neuropeptide Y Immunohistochemistry Pre-atal ontogeny Brain development Aq cerebral aqueduct aca anterior commissure, anteriorpart acp anterior commissure, posterior part Am amygdaloid complex Amb nucleus ambiguus Arc arcuate hypothalamic nucleus BST bed nucleus of the stria terminalis BSTM bed nucleus of the stria terminalis, medial part C cerebellum cc corpus callosum CG central (periaqueductal) grey CPu caudate putamen (striatum) Cu cuneate nucleus DpMe deep mesencephalic nucleus DR dorsal raphe ec external capsule f fornix fi fimbria of the hippocampus fmi forceps minor of the corpus callosum Fr frontal cortex fr fasciculus retroflexus FrPaM frontoparietal cortex, motor area FrPaSS frontoparietal cortex, somatosensory area FStr fundusstriati GP globuspallidus 1C inferior colliculus ic internal capsule icp inferior cerebellar peduncle IG induseum griseum IO inferior olive LC locus coeruleus LH lateral hypothalamus 11 lateral lemniscus lo lateral olfactory tract LRt lateral reticular nucleus LS lateral septum LV lateral ventricle MD mediodorsal thalamus Me median eminence mlf medial longitudinal fasciculus mt mammillothalamic tract MVe medial vestibular nucleus ON olfactory nerve layer OV olfactory ventricle opt optic tract PA gigantocellular reticular nucleus, pars alpha Pa paraventricular nucleus pc posterior commissure PF parafascicular thalamic nucleus PGi paragigantocellular reticular nucleus PO primary olfactory cortex PrH prepositus hypoglossal nucleus py pyramidal tract RCh retrochiasmatic area rf rhinal fissure ROb raphe obscurus Rt reticular thalamic nucleus SC superior colliculus SN substantia nigra Sol nucleus of solitary tract sol solitary tract Sp5 nucleus of spinal tract trigeminal nerve sp5 spinal tract trigeminal nerve st stria terminalis ts tectospinal tract VL ventrolateral thalamic nucleus VPL ventroposterior thalamic nucleus, lateral part ZI zona incerta 2n optic nerve 3V 3rd ventricle 4V 4th ventricle 7 facial nucleus 12 hypoglossal nucleus 

摘      要：The development of neuropeptide Y-like immunoreactive structures in the foetal rat brain was investigated by means of the indirect immunohistofluorescence technique. Neuropeptide Y-like immunoreactive cells and fibres first appeared on day 13 of gestation, in the solitary tract nucleus, lateral reticular nucleus and nucleus ambiguus in the medulla oblongata, and in the primordial inferior colliculus and deep mesencephalic nucleus. Thereafter, neuropeptide Y-like immunoreactive cells and fibres increased in number in many areas including the primary olfactory cortex, the frontoparietal, somatosensory cortex, caudate putamen, lateral hypothalamus, ventrolateral thalamus, amygdala and parafascicular nucleus. The maximum number of cells over the age range studied, namely day 12 of gestation to birth day, occurred at around day 21. On the day of birth, accordingly, there were significantly fewer neuropeptide Y-like immunoreactive cell bodies in a number of brain areas, the most striking deficit being in the ventrolateral thalamus. The present study demonstrates the very early appearance of neuropeptide Y-like immunoreactive structures during foetal brain development. The functional role of the peptide during this period remains, however, to be determined.