T淋巴细胞亚群在NAFLD发病机制中的作用

作     者：许琳 高韬 柯大智 

作者机构：重庆医科大学附属第二医院全科医学科重庆 

出 版 物：《临床医学进展》 (Advances in Clinical Medicine)

年 卷 期：2025年第15卷第1期

页      面：777-786页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：非酒精性脂肪性肝病(NAFLD) 非酒精性脂肪性肝炎(NASH) 肝细胞癌(HCC) CD4+T细胞 CD8+T细胞 γδT细胞 

摘      要：非酒精性脂肪性肝病(Non-alcoholic fatty liver disease, NAFLD)包括一系列的肝脏表现,从肝脏脂肪变性开始,可能演变为非酒精性脂肪性肝炎(Non-alcoholic steatohepatitis, NASH)、纤维化、肝硬化甚至肝细胞癌(Hepatocellular carcinoma, HCC)。其发病率在全球范围内呈上升趋势。尽管NAFLD是一种与代谢紊乱相关的疾病,但它也涉及多种免疫细胞介导的炎症过程。多种免疫细胞通过分泌促炎或抗炎因子来促进或抑制肝细胞炎症,从而影响NAFLD进程。T细胞作为适应性免疫中重要的一环,包括多种淋巴细胞亚群,在NAFLD的进展中发挥着关键作用。本文综述了T淋巴细胞亚群在NAFLD发病机制中的作用,以期为非酒精性脂肪性肝病的药物干预提供新策略。Non-alcoholic fatty liver disease (NAFLD) encompasses a series of liver manifestations. Starting from hepatic steatosis, it may progress to non-alcoholic steatohepatitis (NASH), fibrosis, liver cirrhosis and even hepatocellular carcinoma (HCC). The incidence of NAFLD is on the rise globally. Although NAFLD is a disease concerning metabolic disorders, it also involves various inflammatory processes mediated by immune cells. Various immune cells promote or inhibit liver cell inflammation by secreting pro-inflammatory or anti-inflammatory factors to influence the progression of non-alcoholic fatty liver disease (NAFLD). T cells, as an important part of adaptive immunity, include multiple lymphocyte subsets and play a crucial role in the progression of NAFLD. We review the roles of T lymphocyte subsets in the pathogenesis of NAFLD, expecting to provide new strategies for the pharmaceutical intervention of non-alcoholic fatty liver disease.