Macro-to-nano dynamic hydrogels in sustained transdermal therapy of diffuse ocular surface malignancies

作     者：Jie Chen Yirong Zeng Hao Tian Qixiao Guan Ziyue Huang Hongjing Dou Shiqiong Xu Renbing Jia 

作者机构：Department of OphthalmologyShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Orbital Diseases and Ocular OncologyShanghai 200011China The State Key Laboratory of Metal Matrix CompositesSchool of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China 

出 版 物：《Nano Research》 (纳米研究(英文版))

年 卷 期：2025年第18卷第3期

页      面：372-385页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the Science and Technology Commission of Shanghai(No.22Y31900700) Program of Innovative Research Team of High-Level Local Universities in Shanghai(No.SHSMU-ZDCX20210902) Shanghai Municipal Health Commission(No.2022YQ01) “New Star of Medical College”Young Medical Talents Training Program in Shanghai in 2020 and Cross-Disciplinary Research Fund Project of Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine(No.JYJC202303) 

主　　题：hydrogels targeted therapy conjunctival melanoma ocular surface malignancies 

摘      要：Conjunctival melanoma(CοM)is of high malignancy that diffusely impacts the ocular surface,which is challenging to surgically remove and pose a life-threatening *** one of the most suitable treatment options,drug dropping drugs to the eye surface,however,is limited in its clinical application for CoM treatment due to low drug *** BRAF/MEK inhibitors(BRAF/MEKi)as model drugs,this study proposes a long-lasting eyedrop based on BRAF/MEK dual-targeted liposome-doped dynamic hydrogels with drugs(B/MLDDHs),which can overcome the tear flushing to succeed in effective ocular surface drug delivery.B/MLDDHs encapsulate drugs within lipid bilayers,enhancing drug bioavailability and *** aldehyde dextran and protonated chitosan-based injectable hydrogel system facilitates drug retention on the ocular surface exerting a sustained liposome release,which significantly enhances the drug *** therapeutics,this study demonstrates significantly enhanced in vivo therapeutic effect on orthotopic mouse model of *** their ability to fulfill permeable and long-term release of hydrophobic drugs,B/MLDDHs may serve as a promising platform for non-invasive delivery of various drug molecules,thereby improving therapeutic outcomes for CoM.