Association between the C-reactive protein-albumin-lymphocyte index and metabolic syndrome: evidence from the 2003-2010 national health and nutrition examination survey

作     者：Wu, Lanlan Han, Dunzheng Xue, Yuting He, Shangfei Ma, Zhuang Su, Shuwen Li, Peixin Liu, Shenrong Zhou, Haobin 

作者机构：Guangzhou Med Univ Affiliated Hosp 1 Dept Cardiol Guangzhou 510120 Guangdong Peoples R China 

出 版 物：《DIABETOLOGY & METABOLIC SYNDROME》 (Diabetol. Metab. Syndr.)

年 卷 期：2025年第17卷第1期

页      面：1-11页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：National Outstanding Youth Science Fund Project of National Natural Science Foundation of China 

主　　题：C-reactive protein-albumin-lymphocyte index Metabolic syndrome 

摘      要：Background Metabolic syndrome (MetS) is a global public health problem that significantly impacts human health and quality of life. The relationship between MetS and the C-reactive protein-albumin-lymphocyte (CALLY) index is uncertain. Methods This study analyzed the data of 7,534 individuals from the National Health and Nutrition Examination Survey cycles (2003-2010 cycles). Weighted logistic regression and weighted restricted cubic spline (RCS) curve analyses were used to identify the relationships between the CALLY index and MetS, as well as its components. Results Of the 7,534 participants, 2,086 were diagnosed with MetS. The estimated prevalence of MetS decreased with an increase in the CALLY index (P 0.001). Multivariable logistic regression analysis showed that the odds ratio of MetS was 0.25 (95% confidence interval 0.20-0.32, P 0.001) in the highest CALLY index quartile compared with the lowest quartile after adjusting for confounding variables. The RCS curve analysis revealed non-linear relationships between the CALLY index and MetS or its components. Conclusions This study revealed an inverse relationship between the CALLY index and MetS risk. The CALLY index might be valuable for identifying individuals who are at a high risk of MetS. Clinical trial numberNot applicable.