Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective

作     者：Ziyi Wang Hongying Zhu Wei Xiong Ziyi Wang;Hongying Zhu;Wei Xiong

作者机构：Center for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Anhui Province Key Laboratory of Biomedical Imaging and Intelligent ProcessingInstitute of Artificial IntelligenceHefei Comprehensive National Science CenterHefei 230088China CAS Key Laboratory of Brain Function and DiseaseHefei 230026China Anhui Province Key Laboratory of Biomedical Aging ResearchHefei 230026China 

出 版 物：《Frontiers of Medicine》 (医学前沿(英文版))

年 卷 期：2025年第19卷第2期

页      面：200-225页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：supported by National Key R&D Program of China(Nos.2021YFA0804900 and 2020YFA0112203) the National Natural Science Foundation of China(Nos.32225020,92049304 and 32121002 to W.X.,Nos.32322033,21974130 and 91849116 to H.Z.) the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB39050000) Key Research Program of Frontier Science,CAS(No.ZDBS-LY-SM002) CAS Interdisciplinary Innovation Team(No.JCTD-2018-20) the Youth Innovation Promotion Association CAS,the Fundamental Research Funds for the Central Universities,USTC Research Funds of the Double First-Class Initiative(No.YD9100002001 to W.X.and No.YD9100002005 to H.Z.) CAS Project for Young Scientists in Basic Research(No.YSBR-013) University Synergy Innovation Program of Anhui Province(No.GXXT-2022-033) 

主　　题：metabolism aging senescence age-related diseases metabolomics 

摘      要：The pursuit of healthy aging has long rendered aging and senescence ***-related ailments,such as cardiovascular diseases,diabetes,and neurodegenerative disorders,pose significant threats to *** studies have shed light on the intricate mechanisms encompassing genetics,epigenetics,transcriptomics,and metabolomics in the processes of senescence and aging,as well as the establishment of age-related *** these underlying mechanisms governing aging and related pathology metabolism assumes a pivotal role that holds promise for intervention and *** advancements in metabolomics techniques and analysis methods have significantly propelled the study of senescence and aging,particularly with the aid of multiscale metabolomics which has facilitated the discovery of metabolic markers and therapeutic *** review provides an overview of senescence and aging,emphasizing the crucial role metabolism plays in the aging process as well as age-related diseases.