Transcriptomic modifications across the genome and potential hazards of pulmonary fibrosis caused by metal-organic frameworks

作     者：Zhang, Yule Yang, Zhijin Chen, Mengya Xue, Zhiwei Chen, Jingwei Zhao, Mantong Li, Yuhao Kang, Shifei Dai, Bo Zheng, Lulu Zhuang, Songlin Zhang, Dawei 

作者机构：Engineering Research Center of Optical Instrument and System The Ministry of Education Shanghai Key Laboratory of Modern Optical System Shanghai Engineering Research Center of Environmental Biosafety Instruments and Equipment University of Shanghai for Science and Technology Shanghai200093 China Department of Physics and Electronic Engineering Heze University Heze274015 China College of Science University of Shanghai for Science and Technology Shanghai200093 China Department of Environmental Science and Engineering University of Shanghai for Science and Technology Shanghai200093 China Shanghai Institute of Intelligent Science and Technology Tongji University Shanghai200092 China 

出 版 物：《Science of the Total Environment》 (Sci. Total Environ.)

年 卷 期：2025年第964卷

页      面：178504页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 0837[工学-安全科学与工程] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 

基　　金：This work was financed by Science and Technology Commission of Shanghai Municipality ( 23YF1429400 )  National Key R&D Program of China ( 2021YFE0111300 ) 

主　　题：Lung cancer 

摘      要：Metal-Organic Frameworks (MOFs) have shown great promise in environmental protection, owing to their exceptional properties including ultrahigh surface area and porosity, tunable pore size, and easy chemical functionalization. However, emerging evidence from experimental studies indicates that MOFs have side effects on human health due to metal ions doping, resulting in excessive reactive oxygen species (ROS) production, pro-inflammatory responses, and liver fibrosis. In this study, we investigated the impact of MOF-199 on human bronchial epithelial (HBE) cells by using transcriptome sequencing analysis. The results indicated that the stimulation of MOF-199 enhanced ROS generation, upregulated cytoplasmic Ca2+ levels, then activated the Grb2/SOS/Ras/Raf pathway, induced cell apoptosis, and ultimately resulted in lung fibroblasts through TGF-β secretion. The results were validated in vitro and in vivo. Therefore, it is necessary to carefully evaluate the nanosafety of MOF-199 in environment treatments. © 2025