High-performance Flow Chemistry Platform for Scalable Continuous Synthesis of Branched Block Copolymers with Precise Chain Structures

作     者：Bang-Bang Wang Zhuang Zhang Jing-Tao Wang Li Pan Yue-Sheng Li Dong-Po Song 

作者机构：Tianjin Key Laboratory of Composite and Functional MaterialsSchool of Materials Science and EngineeringTianjin UniversityTianjin 300350China School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学(英文版))

年 卷 期：2025年第43卷第3期

页      面：457-467页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：financially supported by the National Natural Science Foundation of China(No.22071176) 

主　　题：Continuous flow synthesis Ring opening metathesis polymerization Branched copolymer 

摘      要：Cutting-edge research has primarily focused on flow synthesis of linear block copolymers,lacking the ability for manipulating chain architectures for more extensive ***,we develop a flow chemistry platform for the continuous microflow synthesis of bottlebrush block copolymers(BBCPs)using a grafting-through *** involves performing ring-opening metathesis polymerization(ROMP)of two different macromonomers within two microfluidic reactors connected in *** microflow environment allows for complete monomer conversion within a few tens of seconds,benefiting from the superior mixing efficiency achieved in Z-shaped channels as indicated by both theoretical simulations and experimental ***,a library of well-defined BBCPs of up to 528 distinct samples can be produced within one day through automation of the continuous procedure,while keeping precise control on degree of polymerization(DP4)and polydispersity indices(PDI1.2).The synthetic method is generally applicable to different macromonomers with different compositions and contour lengths,yielding libraries of branched block copolymers with great diversity in physiochemical properties and chain *** work presents a powerful platform for high-throughput production of branched copolymers,significantly lowering the costs of the materials for real applications.