Genomic characteristics of a Streptococcus suis of ST353 resulting in severe endophthalmitis with bilateral deafness

作     者：Liang Shen Yanfei Tong Shichao Li Yuda Chen Ruhan A Zhen Li Wenling Wang Lijuan Yin Jiuming Zou Ziyong Sun Changcheng Wu Wenjie Tan Liang Shen;Yanfei Tong;Shichao Li;Yuda Chen;Ruhan A;Zhen Li;Wenling Wang;Lijuan Yin;Jiuming Zou;Ziyong Sun;Changcheng Wu;Wenjie Tan

作者机构：Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021Hubei ProvinceChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China School of Public HealthBaotou Medical CollegeBaotou 014030Inner MongoliaChina Collaborative Innovation Centre of Regenerative Medicine and Medical BioResourse Development and Application Co-constructed by the Province and MinistryGuangxi Medical UniversityNanning 530021Guangxi ProvinceChina State Key Laboratory of Food Nutrition and SafetyKey Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&TechnologyTianjin 300457China Department of Laboratory MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina 

出 版 物：《Infectious Diseases & Immunity》 (感染性疾病与免疫(英文))

年 卷 期：2025年第5卷第1期

页      面：36-43页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported by National Natural Science Foun­dation of China(82002192,32302218) General project of Natural Science Foundation of Hubei Province(2019CFA016,2022CFB539) Young and middle-aged Talents Project of Hubei Provincial Education Department(Q20222605) Tianjin Munic­ipal Science and Technology Committee(21JCQNJC01410) China Postdoctoral Science Foundation(2021M702460) Sci­ence and Technology Plan(in the field of Medical and health care)of Xiangyang(2022YL05B,2022YL12A) National Sci­ence and Technology Basic Resources Survey Special of China(2019FY01206) 

主　　题：Streptococcus suis Endophthalmitis Meningitis Genome sequencing Comparative genomics 

摘      要：Background:Streptococcus suis(***)can be transmitted to humans through exposure to pigs or consumption of raw pork and causes serious *** infection through skin abrasions is considered an important route of transmission,few studies have reported skin injuries in patients during exposure or before *** study explored a rare instance of intraocular infection and bilateral deafness caused by *** and emphasized the importance of timely diagnosis and treatment to prevent disease ***:The diagnosis was made on the basis of clinical symptoms,imaging,molecular detection,and isolated culture *** susceptibility testing was conducted to determine the effectiveness of ***-genome sequencing was used to identify the strain’s sequence type and serotype as well as the presence of pathogenicity islands(PAIs).Results:A patient with intraocular infection and bilateral deafness was diagnosed with an *** *** infection was hypothe­sized to result from interspecies transmission due to the patient’s occupation and recent skin *** isolated strain was sensitive to ampicillin,ceftriaxone,vancomycin,linezolid,levofloxacin,and ***-genome sequencing revealed that the strain belonged to sequence type 353 and serotype 2,showing close similarity to strains isolated from wild boars in Chinese *** strain lacked the 89 complete kb PAI but had a 33 kb PAI with high similarity,potentially indicating variable ***:This study highlights the importance of employing multiple diagnostic strategies for the timely identification and treatment of *** *** presence of a potentially less virulent strain emphasizes the need for continuous surveillance and monitoring of emerging *** infections,particularly in Asian countries with high-risk populations associated with the pig farming industry.