Ascending aorta dilatation indicates obstructive sleep apnea in Chinese patients with cardiovascular disease

作     者：Qiu, Luwen Li, Pingwei Ding, Zhaohui Wang, Jing Huang, Ning Hua, Lu Xi, Qunying 

作者机构：Chinese Acad Med Sci Pulm Vasc Dis Ward Fuwai Hosp 12 Langshan Rd Shenzhen 518057 Guangdong Provi Peoples R China Chinese Acad Med Sci Ward 2 Cardiac Arrhythmia Fuwai Hosp Shenzhen 518057 Guangdong Provi Peoples R China 

出 版 物：《SLEEP AND BREATHING》 (Sleep Breathing)

年 卷 期：2025年第29卷第1期

页      面：1-7页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：Shenzhen Clinical Research Center for Cardiovascular Disease Fund 

主　　题：Obstructive sleep apnea Echocardiography Ascending aorta diameter Diagnosis 

摘      要：PurposeObstructive sleep apnea (OSA) is prevalent in patients with cardiovascular disease (CVD), and is linked to worsened outcomes. Screening tools are essential for early detection and intervention. We aimed to investigate the role of ascending aorta diameter (AAD) obtained from echocardiography in identifying OSA in CVD patients. MethodsWe examined the correlation between AAD and sleep apnea test parameters in 721 hospitalized CVD (including hypertension, coronary artery disease, chronic heart failure, atrial fibrillation, and pulmonary hypertension) patients. Multivariate analyses were performed on all findings. Receiver operator characteristic curve (ROC) analyses were used to determine the role of AAD in detecting OSA. ResultsAAD was significantly higher in patients with OSA than those without OSA. AAD significantly correlated with apnea-hypopnea index (AHI) and saturation-related parameters. In comparison, pulmonary artery diameter did not correlate with AHI but had significant negative correlations with the saturation-related parameters. The area under the ROC of AAD for detecting OSA in CVD patients was 0.70 (95% CI, 0.65-0.74;p 0.001). In the chronic heart failure subgroup, the area under the curve for AAD was 0.75 (95% CI 0.67-0.82, p 0.001). The optimal cut-off value of AAD was 31.5 mm, resulting in a sensitivity of 73%, a specificity of 55% in CVD patients, and 29.5 mm with a sensitivity of 82% and a specificity of 64% in chronic heart failure patients. ConclusionsAAD was associated with the severity of OSA. AAD could be a valuable tool for identifying OSA in CVD patients, particularly in patients with chronic heart failure.