Hsp90: Bringing it all together

作     者：Karras, Georgios Ioannis Colombo, Giorgio Kravats, Andrea N. 

作者机构：Univ Texas MD Anderson Canc Ctr Dept Genet Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr UTHealth Houston Grad Sch Biomed Sci Genet & Epigenet Grad Program Houston TX 77030 USA Univ Pavia Dept Chem Pavia Italy Miami Univ Dept Chem & Biochem Oxford OH 45056 USA 

出 版 物：《CELL STRESS & CHAPERONES》 

年 卷 期：2025年第30卷第1期

页      面：69-79页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：Associazione Italiana Ricerca sul Cancro (AIRC) [R01CA295874, R35GM146963] James and Beth Lewis Professorship [IG 2022-ID, 27139] Cancer Prevention & Research Institute of Texas (CPRIT) Scholar in Cancer Research 

主　　题：Hsp90 Proteostasis Structure-function Evolution Modulators 

摘      要：Heat-shock protein 90 (Hsp90) is an ancient and multifaceted protein-folding machine essential for most organisms. The past 40 years have uncovered remarkable complexity in the regulation and function of Hsp90, which dwarfs most other machines in the cell in sophistication. Here, we propose four analogies to illustrate Hsp90 s sophistication: a multifunctional Swiss Army knife, an automobile engine and its controls, a switchboard acting as a hub and directing signals, and an orchestra conductor setting the tempo of a symphony. Although each of these analogies represents some key Hsp90 activities, none of them captures the entirety of Hsp90 s complexity. Together, these roles enable Hsp90 to support both homeostasis and differentiation, both cellular stability and adaptability. At the 11th International Conference on the Hsp90 Chaperone Machine, the consensus was that to understand this major guardian of proteostasis, we need to study how the many facets of Hsp90 s function influence each other. We hope that these analogies will help to conceptually integrate the many roles of Hsp90 in proteostasis and help the field develop the practical applications of Hsp90 modulators.