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Bioactive hydrogel formulations for regeneration of pathological bone defects

作     者:Li, Zuhao Ren, Kaixuan Chen, Jiajia Zhuang, Yaling Dong, Shujun Wang, Jincheng Liu, He Ding, Jianxun 

作者机构:Orthopaedic Medical Center The Second Hospital of Jilin University 4026 Yatai Street Changchun130041 China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences 5625 Renmin Street Changchun130022 China Department of Polymer Materials School of Materials Science and Engineering Shanghai University 333 Nanchen Road Shanghai200444 China The First Outpatient Department Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology Jilin University 6822 Jinhu Road Changchun130021 China 

出 版 物:《Journal of Controlled Release》 (J. Control. Release)

年 卷 期:2025年第380卷

页      面:686-714页

核心收录:

学科分类:0831[工学-生物医学工程(可授工学、理学、医学学位)] 0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 0804[工学-仪器科学与技术] 10[医学] 

基  金:This work was financially supported by the National Natural Science Foundation of China (Grant Nos. 82372391  U23A20523  82202698  82102358  and U21A2099)  the Project of \u201CMedical+X\u201D Interdisciplinary Innovation Team of Norman Bethune Health Science Center of Jilin University (Grant No. 2022JBGS06)  the Project of Youth Interdisciplinary Innovation Team of Jilin University (Grant No. 419070623054)  the Interdisciplinary of Medicine and Engineering Foundation of Shanghai JiaoTong University (Grant No. YG2024QNA21)  and the Jilin Provincial Department of Finance Backbone Talent Program (Grant No. jcsz2023481-10) 

主  题:Regenerative medicine 

摘      要:Bone defects caused by osteoporosis, infection, diabetes, post-tumor resection, and nonunion often cause severe pain and markedly increase morbidity and mortality, which remain a significant challenge for orthopedic surgeons. The precise local treatments for these pathological complications are essential to avoid poor or failed bone repair. Hydrogel formulations serve as injectable innovative platforms that overcome microenvironmental obstacles and as delivery systems for controlled release of various bioactive substances to bone defects in a targeted manner. Additionally, hydrogel formulations can be tailored for specific mechanical strengths and degradation profiles by adjusting their physical and chemical properties, which are crucial for prolonged drug retention and effective bone repair. This review summarizes recent advances in bioactive hydrogel formulations as three-dimensional scaffolds that support cell proliferation and differentiation. It also highlights their role as smart drug-delivery systems with capable of continuously releasing antibacterial agents, anti-inflammatory drugs, chemotherapeutic agents, and osteogenesis-related factors to enhance bone regeneration in pathological areas. Furthermore, the limitations of hydrogel formulations in pathological bone repair are discussed, and future development directions are proposed, which is expected to pave the way for the repair of pathological bone defects. © 2025 Elsevier B.V.

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