Three-dimensional complementary breast ultrasound (3D CBUS): Improving 3D spatial resolution uniformity with orthogonal images

作     者：Park, Claire Keun Sun Aziz, Amal Trumpour, Tiana Bax, Jeffrey Scott Tessier, David Gyacskov, Igor Gardi, Lori Fenster, Aaron 

作者机构：Western Univ Schulich Sch Med & Dent Dept Med Biophys London ON Canada Robarts Res Inst 1151 Richmond St N London ON N6A 3K7 Canada Harvard Med Sch Brigham & Womens Hosp Dept Radiat Oncol Boston MA USA Harvard Med Sch Dana Farber Canc Inst Boston MA USA Western Univ Fac Engn Sch Biomed Engn London ON Canada Western Univ Schulich Sch Med & Dent Dept Med Imaging Div Imaging Sci London ON Canada 

出 版 物：《MEDICAL PHYSICS》 (Med. Phys.)

年 卷 期：2025年第52卷第4期

页      面：2438-2453页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 1009[医学-特种医学] 10[医学] 

基　　金：Ontario Institute for Cancer Research Ontario Institute for Cancer Research (OICR) Imaging Program Canadian Institutes of Health Research (CIHR) Natural Sciences and Engineering Research Council (NSERC) of Canada NSERC Canada Graduate Scholarships Doctoral (CGS-D) program, Postdoctoral Fellowship (PDF) program Western Graduate Research Scholarship (WGRS) at the Schulich School of Medicine and Dentistry NSERC Canada Graduate Scholarships Master's (CGS-M) program WGRS at the Faculty of Engineering NSERC CGS-D program WGRS at the Schulich School of Medicine and Dentistry 

主　　题：automated breast ultrasound complementary breast ultrasound image reconstruction image visualization orthogonal images resolution uniformity three-dimensional ultrasound 

摘      要：BackgroundWith increasing evidence supporting three-dimensional (3D) automated breast (AB) ultrasound (US) for supplemental screening of breast cancer in increased-risk populations, including those with dense breasts and in limited-resource settings, there is an interest in developing more robust, cost-effective, and high-resolution 3DUS imaging techniques. Compared with specialized ABUS systems, our previously developed point-of-care 3D ABUS system addresses these needs and is compatible with any conventional US transducer, which offers a cost-effective solution and improved availability in clinical practice. While conventional US transducers have high in-plane resolution (axial and lateral), their out-of-plane resolution is constrained by the poor intrinsic elevational US resolution. Consequently, any oblique view plane in an acquired 3DUS image will contain high in-plane and poor out-of-plane resolution components, diminishing spatial resolution uniformity and overall diagnostic *** develop and validate a novel 3D complementary breast ultrasound (CBUS) approach to improve 3DUS spatial resolution uniformity using a conventional US transducer by acquiring and generating orthogonal 3DUS *** previously developed a cost-effective, portable, dedicated 3D ABUS system consisting of a wearable base, a compression assembly, and a mechanically driven scanner for automated 3DUS image acquisition, compatible with any commercial linear US transducer. For this system, we have proposed 3D CBUS approach which involves acquiring and registering orthogonal 3DUS images (VA${V}_A$ and VB${V}_B$) with an aim of overcoming the poor resolution uniformity in the scanning direction in 3D US images. The voxel intensity values in the 3D CBUS image are computed with a spherical-weighted algorithm from the original orthogonal 3DUS images. Experimental validation was performed with 2DUS frame densities of 2, 4, 6 frames mm-1 using an agar-based phantom with a speed o