Polyprenylated Xanthones Isolated from Garcinia Resins and Their Beneficial Effects on Rice Blast Disease

作     者：Li, Ke-Ming Zheng, Shu-Min Dong, Xian Zeng, Zi-Ying Yang, Guangyi Yan, Yong-Ming Cheng, Yong-Xian 

作者机构：Shenzhen Univ Med Sch Inst Inheritance Based Innovat Chinese Med Sch PharmGuangdong Prov Key Lab Chinese Med Ingre Shenzhen 518060 Peoples R China Shenzhen Hosp Integrated Tradit Chinese & Western Dept Pharm Shenzhen 518104 Peoples R China Yunnan Univ Chinese Med Coll Tradit Chinese Pharm Kunming 650500 Peoples R China 

出 版 物：《JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY》 (J. Agric. Food Chem.)

年 卷 期：2025年第73卷第5期

页      面：2920-2934页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 09[农学] 0703[理学-化学] 0901[农学-作物学] 

基　　金：Yunnan Provincial Science and Technology Department [2017YFD0201402] National Key Research and Development Program of China "Research and Development of Comprehensive Technologies on Chemical Fertilizer and Pesticide Reduction and Synergism [868-000005031125] SZU Top Ranking Project [2019FF002(-003)] Yunnan Provincial Science and Technology Department-Applied Basic Research Joint Special Funds of Yunnan University of Chinese Medicine 

主　　题：Garcinia resin xanthones antifungal activity Magnaporthe grisea action mechanism transcriptome sequencing 

摘      要：Five undescribed polyprenylated xanthones (1, 3, 4, 22, and 23) and 27 known compounds were isolated from Garcinia resins, and the antifungal activities of 15 of them were investigated. Compound 7 exhibited notable in vitro antifungal effects against Magnaporthe grisea with an IC50 value of 3.54 mu g/mL, superior to isoprothiolane (10.30 mu g/mL), and showed an excellent protective efficiency of 78.4% at 200 mu g/mL against RB (rice blast), equivalent to isoprothiolane (87.2%). Its antifungal activity may be related to the destruction of the cell membrane and the effect of absorption and utilization of sugar by the mycelium, which was proven by the transcriptome sequencing and preliminary mechanism, showing a good application prospect for replacing agrochemical fungicides in the control of RB disease.