铁死亡与激素性股骨头坏死的研究进展及相关铁死亡基因在骨代谢或氧化应激方面的讨论

作     者：王绍庚 黄富超 汤家骏 

作者机构：深圳大学第二附属医院创伤骨科与矫形外科广东 深圳 广东医科大学深圳宝安临床医学院广东 深圳 暨南大学附属第二临床医学院广东 深圳 

出 版 物：《临床医学进展》 (Advances in Clinical Medicine)

年 卷 期：2025年第15卷第1期

页      面：1717-1730页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：激素性股骨头坏死 铁死亡 氧化应激 

摘      要：背景:越来越多研究表明铁死亡可能参与激素性股骨头坏死的发生与发展。目的:探讨铁死亡与激素性股骨头坏死的关系,为其诊治提供新的思路。方法:以“铁死亡,股骨头坏死为中文检索词,以“ferroptosis, necrosis of the femoral head为英文检索词,检索PubMed、Science Citation Index Expanded、ScienceDirect、Scopus、万方、维普、中国知网数据库,筛选激素性股骨头坏死与铁死亡研究相关文章进行综述分析。结果与结论:① 铁死亡在激素性股骨头坏死发病中起重要作用。② 激素性股骨头坏死中铁死亡的发生受到多种机制通路调控。通过生物信息学方法筛选出的许多激素相关性股骨头坏死铁死亡相关基因仍需进一步的体内体外实验验证。③ 目前关于激素性股骨头坏死铁死亡相关机制尚不明确,亟需深入探明两者的作用机制,有望为激素性股骨头坏死提供新的治疗思路。Background: Ferroptosis may be involved in the development and progression of steroid-induced osteonecrosis of the femoral head. Objective: To explore the relationship between ferroptosis and steroid-induced osteonecrosis of femoral head, and to provide new ideas for steroid-induced osteonecrosis of femoral head diagnosis and treatment. Methods: Using “ferroptosis, osteonecrosis of the femoral head as the Chinese search term and “ferroptosis, necrosis of the femoral head as the English search term, we searched the PubMed, Science Citation Index Expanded, ScienceDirect, Scopus, Wanfang and VIP databases, and screened the articles related to the study of ferroptosis and steroid-induced osteonecrosis of femoral head from the establishment of the databases to 2024, and conducted a review analysis. Results and Conclusions: ① Ferroptosis plays an important role in the pathogenesis of steroid-induced osteonecrosis of the femoral head. ② Ferroptosis in steroid-induced osteonecrosis of femoral head is regulated by various mechanisms. Many of the genes associated with ferroptosis in steroid-induced osteonecrosis of the femoral head screened by bioinformatics methods still need to be validated by further in vivo and in vitro experiments. ③ The mechanism of ferroptosis in steroid-induced osteonecrosis of the femoral head is still unclear. Further investigation on the mechanism of action of both is expected to provide new therapeutic ideas for steroid-induced osteonecrosis of the femoral head.