Utilizing Tissues Self-Assembled in Fiber Optic-Based "Chinese Guzheng Strings" for Contractility Sensing and Drug Efficacy Evaluation: A Practical Approach

作     者：Li, Tianliang Wan, Zhongjun Wang, Qian'ao Qiao, Feng Pan, Ganlin Zhao, Chen Zhu, Yongwen Zhou, Haotian Tan, Yuegang Zhou, Zude Zhang, Donghui 

作者机构：Wuhan Univ Technol Sch Mech & Elect Engn Wuhan 430070 Hubei Peoples R China Hubei Univ Stem Cells & Tissue Engn Manufacture Ctr Sch Life Sci State Key Lab Biocatalysis & Enzyme Engn Wuhan 430062 Hubei Peoples R China Huazhong Univ Sci & Technol Union Hosp Cardiovasc Inst Tongji Med Coll Wuhan 430022 Hubei Peoples R China 

出 版 物：《SMALL》 (Small)

年 卷 期：2025年第21卷第7期

页      面：e2406144页

核心收录：

学科分类：12[管理学] 1201[管理学-管理科学与工程(可授管理学、工学学位)] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 

基　　金：National Key Research and Development Program of China National Natural Science Foundation of China Key Research and Development Program of Hubei Province [2024BCB056] 2021YFA1101902 

主　　题：contractility measurement fiber Bragg grating human-engineered heart tissue 

摘      要：Recent advances in drug design and compound synthesis have highlighted the increasing need for effective methods of toxicity evaluation. A specialized force sensor, known as the light wavelength-encoded Chinese guzheng is developed. This innovative sensor is equipped with optical fiber strings and utilizes a wavelength-encoded fiber Bragg grating (FBG) that is chemically etched to reduce its diameter. This design allows the sensor to detect minimal forces as low as l mu N. This sensor is successfully applied to monitor human-induced pluripotent stem cell-derived human-engineered heart tissue (hEHT) models that can self-assemble and contact optical fiber-based strings. The sensor detects micro newton contraction forces in real-time by measuring the wavelength drift resulting from hEHT contractions. In addition, the sensor is precise and durable, exhibiting a fatigue resistance of up to 800 000 cycles, making it suitable for long-term monitoring. The device effectively measured the contractile force of the hEHTs under various physiological conditions, including natural contraction, electrical stimulation, and stretching. Moreover, multichannel detection enables the study and demonstration of short- and long-term effectiveness of multiple drugs. This breakthrough sensor addresses the critical need for high-precision real-time monitoring in drug evaluation and provides a solid foundation for screening drugs to treat cardiomyopathy.