Spectrum of Otological Manifestations in Treacher Collins Syndrome: A Case Series of 9 Patients

作     者：Ansari, Shehbaz Basappa, Eric R. Markee, Peter C. Dixon, Chanae Bhabad, Sudeep H. 

作者机构：Department of Diagnostic Radiology and Nuclear Medicine Rush University Medical Center ChicagoIL United States 

出 版 物：《Journal of Computer Assisted Tomography》 (J. Comput. Assisted Tomogr.)

年 卷 期：2025年

页      面：2025 Jan 27页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100106[医学-放射医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Pediatrics 

摘      要：Treacher Collins syndrome (TCS) is an uncommon congenital disorder predominantly involving craniofacial, orbital, and otological structures. The various ear malformations seen in 9 patients with TCS are described. TCS predominantly affects the external and middle ear structures, with inner ear structures being relatively spared, not unexpected given the dual embryological origin of the human ear. The external and middle ear malformations were categorized and graded as those involving the ear pinna, external auditory canal, tympanic cavity, ossicles, facial nerve canal, oval window, and bony labyrinth for all 9 patients. The ear malformations were symmetric in the majority, and the patients with higher grades of microtia were found to have a more severe category of other otological malformations. Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.