液体活检及其联合影像学在良恶性肺结节诊断的研究进展

作     者：阚杰 牟康 李小松 

作者机构：重庆医科大学附属第一医院临床分子医学检测中心重庆 

出 版 物：《临床医学进展》 (Advances in Clinical Medicine)

年 卷 期：2025年第15卷第1期

页      面：1925-1931页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：肺结节 液体活检 影像学 诊断 

摘      要：肺结节是早期肺癌的一种表现,检出率逐年增高,早期诊断依赖于多种影像学,由于假阳性率高而无法精准评估,存在过度诊断。液体活检通过非侵入式方法对外周血中循环肿瘤细胞、DNA甲基化及非编码RNA进行检测,具有较高灵敏度和特异性,逐渐成为肿瘤精准医疗领域强有力的诊断依据。本文就液体活检及其联合临床影像学在良恶性肺结节诊断中的研究进展进行综述。Pulmonary nodules are a manifestation of early-stage lung cancer, with detection rates increasing year by year. Early diagnosis relies on various imaging techniques, but the high rate of false positives makes it difficult to assess accurately, leading to overdiagnosis. Liquid biopsy, a non-invasive method, detects circulating tumor cells, DNA methylation, and non-coding RNA in peripheral blood with high sensitivity and specificity, gradually becoming a powerful diagnostic basis in the field of precision oncology. This article reviews the research progress of liquid biopsy and its combination with clinical imaging in the diagnosis of benign and malignant pulmonary nodules.