Multi-level genomic convergence of secondary aquatic adaptation in marine mammals

作     者：Shixia Xu Lei Shan Ran Tian Zhenpeng Yu Di Sun Zhenhua Zhang Inge Seim Ming Zhou Linxia Sun Na Liang Qian Zhang Simin Chai Daiqing Yin Luoying Deme Tianzhen Wu Yongjie Chen Zhikang Xu Yu Zheng Wenhua Ren Guang Yang 

作者机构：Jiangsu Key Laboratory for the Biodiversity Conservation and Sustainable Utilization in the Middle and Lower Reaches of Yangtze River BasinCollege of Life SciencesNanjing Normal UniversityNanjing 210023China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)Guangzhou 511458China Integrative Biology LaboratoryCollege of Life SciencesNanjing Normal UniversityNanjing 210023China School of Biology and Environmental ScienceQueensland University of TechnologyBrisbaneQLD 4002Australia 

出 版 物：《The Innovation》 (创新(英文))

年 卷 期：2025年第6卷第3期

页      面：74-83,73页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 0905[农学-畜牧学] 09[农学] 071007[理学-遗传学] 090501[农学-动物遗传育种与繁殖] 

基　　金：supported by the National Key Programme of Research and Development,Ministry of Science and Technology(2022YFF1301600)to G.Y the Key Project of the Na tional Natural Science Foundation of China(32030011)to G.Y the National Natural Science Foundation of China(32070409,32270453,32270442,32070408,and 32270441)to S.X.,W.R.,L.S.,and R.T the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),Qinglan Project of Jiangsu Province to S.X the Specially-Appointed Professor Program of Jiangsu Province to I.S the Jiangsu Foreign Expert Bureau to I.S the Jiangsu Provincial Department of Technology(JSSCTD202142)to I.S the PI Project of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(GML2021GD0805)to G.Y 

主　　题：molecular mechanisms convergent evolution marine mammals secondary aquatic adaptation amino acid substitutions suppress cancer cell multiomics functional experimentsincluding 

摘      要：Marine mammals provide a valuable model for studying the molecular basis of convergent evolution during secondary aquatic *** multiomics data and functional experiments,including CRISPR-Cas9 mouse models and luciferase reporter assays,this study explored the molecular mechanisms driving this transition across coding regions,regulatory elements,and genomic *** amino acid substitutions in APPL1P378L and NEIL1E71G were found to promote lipid accumulation and suppress cancer cell proliferation,likely contributing to the evolution of extensive blubber layers and cancer *** evolved conserved non-exonic elements(CNEs)and lineage-specific regulatory variations were shown to influence the activity of nearby genes(e.g.,NKX3-2,SOX9,HAND2),shaping cetacean limb ***,convergent shifts in topologically associating domains(TADs)across cetaceans and pinnipeds were implicated in the regulation of ASXL3 and FAM43B expression,playing a role in the formation of thickened blubber layers and mitigating cancer *** variations within conserved TADs were associated with the expression of neuronal genes,including NUP153 and ID4,potentially driving cognitive and social *** findings provide novel insights into the molecular foundations of the convergent evolution of secondary aquatic adaptations in mammals.