Utilizing Noncovalent Interactions to Lock and Facilitate Bond Rotation Enables Wide-Range Modulation of the Thermal Isomerization Dynamics of Photoswitches

作     者：Xin-Lin Cao Jia-Lin Yao Zhen-Nan Shen Zhi Li Bo Qiao 

作者机构：School of Physical Science&TechnologyShanghaiTech UniversityShanghai 201210 

出 版 物：《CCS Chemistry》 (中国化学会会刊(英文))

年 卷 期：2025年第7卷第3期

页      面：786-797页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by ShanghaiTech University 

主　　题：photoswitch noncovalent interaction isomerization dynamics thermal relaxation 

摘      要：The wide application of photoswitches requires control over their isomerization *** noncovalent interactions is a promising strategy as it offers active regulation ***,this control strategy has not yet been explored in-depth to reach its full *** this work,we demonstrate that by directing noncovalent interactions to the central rotating bond of indigo-based photoswitches,their thermal relaxation dynamics were altered in two opposite directions(either slowed down or sped up)allowing for modulating the relaxation half-lives across four orders of *** importantly,our work established two distinct and orthogonal working mechanisms of noncovalent control over isomerization:(1)Thermodynamic stabilization of photoisomers;and(2)Facilitating an alternative reaction pathway through Brønsted/Lewis acid *** two-directional modulation(resembling agonists and inverse agonists in biological systems)via two orthogonal working mechanisms will enable more delicate manipulation of photoswitches for advanced applications.