Mild photothermal therapy-enhanced nano-ferroptosis inducer for potent treatment of advanced prostate cancer

作     者：Xiao Hu Fei Li Xin-Hang Qian Yu-Sen Zhang Shuai Ke Yun-Xia Jin Shuai Yuan Yuan-Yuan Zhang Rui Li Lei Cao Lang Rao Xian-Tao Zeng Ling-Ling Zhang 

作者机构：Center for Evidence-Based and Translational MedicineZhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Chemical BiologyShenzhen Bay LaboratoryShenzhen 518132China Department of UrologyZhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Collaborative Innovation Center for Advanced Organic Chemical MaterialsMinistry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules&College of Chemistry and Chemical EngineeringHubei UniversityWuhan 430062China Xinjiang Key Laboratory of Solid State Physics and DevicesSchool of Physics Science and TechnologyXinjiang UniversityUrumqi 830017China 

出 版 物：《Nano Research》 (纳米研究(英文版))

年 卷 期：2025年第18卷第4期

页      面：375-387页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.12204358 and 62204214) the Young Top-notch Talent Cultivation Program of Hubei Province(X.-T.Z.) the Fundamental Research Funds for the Central Universities(No.2042023kf0091) the Youth Interdisciplinary Special Fund of Zhongnan Hospital of Wuhan University(No.ZNQNJC2022005) 

主　　题：prostate cancer ferroptosis mild photothermal therapy chemodynamic therapy mesoporous polydopamine 

摘      要：Androgen deprivation therapy(ADT)and androgen receptor signaling inhibitors(ARSis)often have limited efficacy in patients with advanced prostate cancer(PCa)(especially AR-negative).Inducing ferroptosis in PCa cells is an attractive therapeutic *** this work,mesoporous polydopamine nanoparticles(MPDA NPs)were developed to simultaneously deliver Cu^(+)/Cu^(2+)ion pairs and glutathione peroxidase 4(GPX4)inhibitor RSL3 to tumor sites for enhanced treatment of *** prepared MPDA-Cu-RSL3@HA(MPCRH)NPs induced ferroptosis by promoting lipid peroxidation and regulating phospholipid profiles in PCa cells,and the above effects were further enhanced by mild photothermal therapy(mPTT)without damaging normal *** can promote reactive oxygen species(ROS)generation and degrade tumor extracellular matrix in vivo to promote nanodrugs intratumoral *** short,this work shows the great application potential of mPTT-enhanced nano-ferroptosis inducers in the field of PCa treatment,in order to provide a reasonable paradigm for nanodrug development and PCa treatment.