Immuno'logical (the scientific updates you wouldn't dare to read anywhere else): X chromosome, Xist, and female autoimmunity

作     者：Lacombe, Valentin 

作者机构：Service de Médecine interne et polyvalente centre hospitalier du Haut-Anjou 1 quai du Dr Lefèvre Château-Gontier 53200 France MitoLab unité MITOVASC UMR CNRS 6015 Inserm U1083 SFR ICAT université d'Angers Angers 49000 France 

出 版 物：《Revue de Medecine Interne》 (Rev. Med. Interne)

年 卷 期：2025年第46卷第6期

页      面：348-351页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Autoimmunity Non-coding RNA Toll-like receptor 7 X chromosome Xist 

摘      要：This first article in the Immuno logical series explores the role of the X chromosome and the non-coding RNA Xist in the female predisposition to autoimmune diseases, by breaking down three fundamental research studies to make them more digestible for non-experts. Xist is a non-coding RNA that inactivates one of the two X chromosomes in every female cell by wrapping around it. Here, we dive into how Xist is involved in the production of anti-RNP antibodies in lupus, how the TLR7 gene can be a rebel and escape Xist s control, and how a lack of affinity between Xist and its X chromosome can contribute to other autoimmune diseases. Let s be serious without taking ourselves too seriously, and uncover the fascinating world of Xist in autoimmunity! © 2025 Société Nationale Française de Médecine Interne (SNFMI)