In vitro inhibition of carcinogen-induced mutagenicity by <i>Cassia occidentalis</i> and <i>Emblica officinalis</i>

作     者：Sharma, N Trikha, P Athar, M Raisuddin, S 

作者机构：Jamia Hamdard Hamdard Univ Dept Med Elementol & Toxicol New Delhi 110062 India 

出 版 物：《DRUG AND CHEMICAL TOXICOLOGY》 (药物与化学毒理学)

年 卷 期：2000年第23卷第3期

页      面：477-484页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

基　　金：Lady Tata Memorial Trust 

主　　题：黄曲霉毒素B1/代谢 黄曲霉毒素B1/毒性 抗诱变药/药理学 苯并芘/代谢 苯并芘/毒性 致癌物/代谢 致癌物/毒性 山扁豆属 大戟科 微粒体 肝/药物作用 微粒体 肝/代谢 诱变力试验 诱变剂/代谢 诱变剂/毒性 植物提取物/药理学 植物 药用 鼠伤寒沙门菌/药物作用 鼠伤寒沙门菌/遗传学 

摘      要：Aqueous extracts of Cassia occidentalis Linn. (Leguminoceae) and Emblica officinalis Gaertn. (Euphorbiaceae) were screened for effectiveness in inhibiting mutagenicity of aflatoxin B-1 (AFB(1)) and benzo[a]pyrene (B[a]P) in the Ames test. Antimutagenicity was evaluated using Salmonella typhimurium strains TA 98 and TA 100. In the assay, metabolic activation of AFB(1) (0.5 mu g/plate) and B[a]P (1 mu g/plate) was mediated by rat liver S9 preparation. Although both plants inhibited mutagenicity, E. officinalis had more inhibitory effect than C. occidentalis. Their action is possibly mediated through interactions with microsomal activating enzymes. Their inhibitory action on chromosomal aberrations together with present results suggest that these plants have potent antimutagenic and anticarcinogenic activities against mutagens requiring metabolic activation.