Genetic diversity and C2-like subgenogroup strains of enterovirus 71, Taiwan, 2008

作     者：Huang, Yuan-Pin Lin, Tsuey-Li Hsu, Li-Ching Chen, Yu-Ju Tseng, Yin-Hsin Hsu, Chiu-Chu Fan, Wen-Bin Yang, Jyh-Yuan Chang, Feng-Yee Wu, Sheng 

作者机构：Ctr Dis Control Res & Diagnost Ctr Dept Hlth Taipei Taiwan Taipei Med Univ Sch Med Lab Sci & Biotechnol Taipei Taiwan 

出 版 物：《VIROLOGY JOURNAL》 (病毒学杂志)

年 卷 期：2010年第7卷第1期

页      面：277-277页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 071005[理学-微生物学] 10[医学] 

基　　金：Taiwan CDC National Research Program for Genomic Medicine 

主　　题：Basic Local Alignment Search Tool Neutralization Antibody Titer Human Rhinovirus Human Enterovirus Elicit Neutralize Antibody 

摘      要：Background: Human enterovirus 71 (EV-71) is known of having caused numerous outbreaks of hand-foot-mouth disease, and other clinical manifestations globally. In 2008, 989 EV-71 strains were isolated in Taiwan. Results: In this study, the genetic and antigenic properties of these strains were analyzed and the genetic diversity of EV-71 subgenogroups surfacing in Taiwan was depicted, which includes 3 previously reported subgenogroups of C5, B5, and C4, and one C2-like subgenogroup. Based on the phylogenetic analyses using their complete genome nucleotide sequences and neutralization tests, the C2-like subgenogroup forms a genetically distinct cluster from other subgenogroups, and the antisera show a maximum of 128-fold decrease of neutralization titer against this subgenogroup. In addition, the subgenogroup C4 isolates of 2008 were found quite similar genetically to the Chinese strains that caused outbreaks in recent years and thus they should be carefully watched. Conclusions: Other than to be the first report describing the existence of C2-like subgenogroup of EV-71 in Taiwan, this article also foresees a potential of subgenogroup C4 outbreaks in Taiwan in the near future.