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出 版 物:《世界核心医学期刊文摘(皮肤病学分册)》 (Digest of the World Core Medical JOurnals:Dermatology)
年 卷 期:2006年第2卷第6期
页 面:59-59页
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题:HTLV-Ⅰ感染 皮肤T细胞淋巴瘤 T细胞性白血病 临床表现 成人 T淋巴细胞病毒 恶性增殖性疾病 辅助性T淋巴细胞 血清流行病学调查 细胞增生性疾病
摘 要:Adult T-cell leukemia/lymphoma (ATLL) is a malignant proliferation of mature helper T lymphocytes, and is caused by human T-lymphotropic virus type I (HTLV-I); an HTLV-I infection endemic in the Caribbean, south-western Japan, South America and Africa. Seroepidemiological studies suggest that it is also endemic in Brazil. Although carriers of HTLV-I show polyclonal integration of virus in T lymphocytes, only patients with ATLL of various subtypes show monoclonal integration of HTLV-I in tumor cells. Cutaneous T-cell lymphomas (CTCL) are a group of primary cutaneous lymphoproliferative diseases unknown etiology. The two most common presentations of CTCL are mycosis fungoides (MF) and Sézary syndrome (SS). However, both CTCL categories can easily resemble ATLL. Therefore, in HTLV-I endemic areas, differentiation between ATLL and CTCL must be performed, as they have different prognoses and treatment approaches.