Polymorphisms in XRCC1 and glutathione <i>S</i>-transferase genes and hepatitis B-related hepatocellular carcinoma

作     者：Yu, MW Yang, SY Pan, IJ Lin, CL Liu, CJ Liaw, YF Lin, SM Chen, PJ Lee, SD Chen, CJ 

作者机构：Natl Taiwan Univ Coll Publ Hlth Grad Inst Epidemiol Taipei 100 Taiwan Taipei Municipal Jen Ai Hosp Dept Internal Med Div Gastroenterol Taipei Taiwan Natl Taiwan Univ Hosp Hepatitis Res Ctr Taipei Taiwan Natl Yang Ming Univ Vet Gen Hosp Dept Med Taipei 112 Taiwan Natl Yang Ming Univ Sch Med Taipei 112 Taiwan Chang Gung Univ Chang Gung Mem Hosp Liver Res Unit Taoyuan Taiwan 

出 版 物：《JOURNAL OF THE NATIONAL CANCER INSTITUTE》 (国立癌症研究所杂志)

年 卷 期：2003年第95卷第19期

页      面：1485-1488页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Carcinoma Hepatocellular DNA Repair DNA-Binding Proteins Glutathione Transferase 癌 肝细胞 DNA修复 DNA结合蛋白质类 肝炎 乙型 肝肿瘤 Association (Psychology) DNA-Binding Proteins Carcinogen Metabolism DNA XRCC1 gene DNA Repair Hepatitis B Virus-Related Hepatocellular Carcinoma Hepatitis B virus Genotype Glutathione Transferase Human-centered computing Carcinoma 

摘      要：Chronic infection with hepatitis B virus (HBV) causes DNA damage. An arginine (Arg)-to-glutamine (Gln) polymorphism at codon 399 in the XRCC1 gene is putatively associated with DNA damage. In a case-control study of 577 HBV surface antigen carriers with hepatocellular carcinoma (HCC) and 389 HBV carrier control subjects, we investigated the association between this polymorphism and the risk of HCC and assessed whether this association varied with glutathione S-transferase (GST) status;GSTs are involved in carcinogen metabolism. All statistical tests were two-sided. The XRCC1 Gln allele was associated with a dose-dependent increased risk of early-onset HCC (50 years) but not with the risk of late-onset HCC (P-trend =.01). The GSTT1-null genotype alone did not affect risk, but the GSTM1-null genotype was associated with a decreased risk for early-onset HCC. Various combinations of GSTM1 and GSTT1 genotypes differentially modified the association of XRCC1 with HCC (P-interaction =.005);e.g., for individuals with the GSTTI-null/ GSTM1-present genotype, the risk of HCC was greater for those with the Gln/Gln genotype (odds ratio = 8.07, 95% confidence interval = 1.67 to 38.93) than for those with the Arg/Arg genotype. Thus, GST status appears to affect the risk of HCC associated with this XRCC1 polymorphism.