SIMULATION ANALYSIS OF DEFORMATION AND STRESS OF TRACHEAL AND MAIN BROCHIAL WALL FOR SUBJECTS WITH LEFT PULMONARY ARTERY SLING

作     者：Qi, Shouliang Li, Zhenghua Yue, Yong Van Triest, Han J. W. Kang, Yang Qian, Wei 

作者机构：Northeastern Univ Sinodutch Biomed & Informat Engn Sch Shenyang 110167 Peoples R China Northeastern Univ Key Lab Med Imaging Comp Minist Educ Shenyang 110819 Peoples R China China Med Univ Shengjing Hosp Dept Radiol Shenyang 110004 Peoples R China Univ Texas El Paso Coll Engn El Paso TX 79968 USA 

出 版 物：《JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY》 (医学与生物学中的力学杂志)

年 卷 期：2015年第15卷第6期

页      面：1540053-1540053页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：Natural Science Foundation of Liaoning Province Scientific Research Fund of Liaoning Provincial Education Department [L2012080] Fundamental Research Funds for the Central Universities [N130219001] 

主　　题：Fluid-structure interaction computational fluid dynamics left pulmonary artery sling deformation 

摘      要：Left pulmonary artery sling (LPAS) is a kind of severe congenital anomaly, where the stenoses usually occur at trachea and main bronchi for the external compression of the artery sling. Computed tomography (CT) images can provide accurate morphological analysis, but the airflow and its effects on the airway wall are unknown and seldom investigated. In the present study, a uni-directional coupling fluid-structure interaction (UCFSI) method is employed to simulate the deformation and stress of tracheal and main bronchial wall for four LPAS subjects and one health control. Much higher airflow velocity is observed for LPAS subjects due to the stenosis, and the deformation and equivalent stress of airway wall are about 50-900 and 901000 times of the health control, respectively. The direction of tracheal shift may be related to the airway shape, and is opposite to the net reaction force. The influences of inlet flow velocity and wall thickness on the deformation and stress are significant and their relationship is nonlinear. These results suggest that the UCFSI simulation is helpful for the quantitative analysis on the deformation and stress of the airway wall and better understanding of LPAS mechanism.