A Cerebellar Framework for Predictive Coding and Homeostatic Regulation in Depressive Disorder

作     者：Schutter, Dennis J. L. G. 

作者机构：Radboud Univ Nijmegen Donders Inst Brain Cognit & Behav Montessorilaan 3 NL-6525 HR Nijmegen Netherlands 

出 版 物：《CEREBELLUM》 (小脑)

年 卷 期：2016年第15卷第1期

页      面：30-33页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：NIMH NIH HHS [R15MH106957] Funding Source: Medline 

主　　题：Cerebellum Depressive disorder Homeostasis Monitoring Predictive coding Punishment Reward 

摘      要：Depressive disorder is associated with abnormalities in the processing of reward and punishment signals and disturbances in homeostatic regulation. These abnormalities are proposed to impair error minimization routines for reducing uncertainty. Several lines of research point towards a role of the cerebellum in reward- and punishment-related predictive coding and homeostatic regulatory function in depressive disorder. Available functional and anatomical evidence suggests that in addition to the cortico-limbic networks, the cerebellum is part of the dysfunctional brain circuit in depressive disorder as well. It is proposed that impaired cerebellar function contributes to abnormalities in predictive coding and homeostatic dysregulation in depressive disorder. Further research on the role of the cerebellum in depressive disorder may further extend our knowledge on the functional and neural mechanisms of depressive disorder and development of novel antidepressant treatments strategies targeting the cerebellum.