Persistent modifications of hippocampal synaptic function during remote spatial memory

作     者：Pavlowsky, Alice Wallace, Emma Fenton, Andre A. Alarcon, Juan Marcos 

作者机构：Suny Downstate Med Ctr Dept Pathol Robert F Furchgott Ctr Neural & Behav Sci 450 Clarkson Ave Brooklyn NY 11203 USA Suny Downstate Med Ctr Robert F Furchgott Ctr Neural & Behav 450 Clarkson Ave Brooklyn NY 11203 USA Suny Downstate Med Ctr Grad Program Neural & Behav Sci 450 Clarkson Ave Brooklyn NY 11203 USA Suny Downstate Med Ctr Dept Physiol & Pharmacol 450 Clarkson Ave Brooklyn NY 11203 USA NYU Ctr Neural Sci 4 Washington Pl New York NY 10003 USA Ecole Super Phys & Chim Ind Ville Paris Brain Plast Unit CNRS UMR 8249 10 Rue Vauquelin F-75005 Paris France 

出 版 物：《NEUROBIOLOGY OF LEARNING AND MEMORY》 (Neurobiol. Learn. Mem.)

年 卷 期：2017年第138卷第0期

页      面：182-197页

核心收录：

学科分类：0402[教育学-心理学(可授教育学、理学学位）] 04[教育学] 1001[医学-基础医学(可授医学、理学学位)] 

基　　金：Robert Furchgott Society Phillips Foundation NIH [R01MH084038, R03NS081625, R21NS091830] 

主　　题：Hippocampus Memory CA1 Synaptic circuits Remote memory Schema Active place avoidance Synaptic plasticity 

摘      要：A widely accepted notion for a process underlying memory formation is that learning changes the efficacy of synapses by the mechanism of synaptic plasticity. While there is compelling evidence of changes in synaptic efficacy observed after learning, demonstration of persistent synaptic changes accompanying memory has been elusive. We report that acquisition of a hippocampus and long-term potentiation dependent place memory persistently changes the function of CA1 synapses. Using extracellular recordings we measured CA3-CA1 and EC-CA1 synaptic responses and found robust changes in the CA3-CA1 pathway after memory training. Crucially, these changes in synaptic function lasted at least a month and coincided with the persistence of long-term place memories;the changes were only observed in animals that expressed robust memory, and not in animals with poor memory recall. Interestingly, our findings were observed at the level of populations of synapses;suggesting that memory formation recruits widespread synaptic circuits and persistently reorganizes their function to store information. (C) 2016 Elsevier Inc. All rights reserved.