Cover Picture: Proteolytic Actuation of Nanoparticle Self-Assembly (Angew. Chem. Int. Ed. 19/2006)

作     者：Todd J. Harris Geoffrey von Maltzahn Austin M. Derfus Erkki Ruoslahti Sangeeta N. Bhatia Prof. 

作者机构：Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology E19-502D Cambridge MA 02139 USA Fax: (+1) 617-324-0710 These authors contributed equally Department of Bioengineering University of California San Diego La Jolla CA USA Burnham Institute La Jolla CA USA Electrical Engineering and Computer Science/MIT Brigham & Women's Hospital Boston MA USA 

出 版 物：《Angewandte Chemie International Edition》 

年 卷 期：2006年第45卷第19期

学科分类：081704[工学-应用化学] 08[工学] 0817[工学-化学工程与技术] 

主　　题：magnetic properties nanostructures proteases self-assembly triggered assembly 

摘      要：Sterically shielded …︁ …︁ nanoparticles diffuse freely in solution and biological fluids until proteases expressed by cancer cells trigger them to self-assemble. In their Communication on page 3161ff., S. N. Bhatia and co-workers show that complimentary Fe 3 O 4 nanoparticle binding is inhibited by the attachment of protease-cleavable polymers. Cleavage of these polymers triggers “latent nanoparticles to form multimeric assemblies with emergent properties.