<SUP>13</SUP>C-Aminopyrine breath test to evaluate severity of disease in patients with chronic hepatitis C virus infection

作     者：Giannini, E Fasoli, A Chiarbonello, B Malfatti, F Romagnoli, P Botta, F Testa, E Polegato, S Fumagalli, A Testa, R 

作者机构：Univ Genoa Dept Internal Med Gastroenterol Unit I-16132 Genoa Italy Univ Genoa Dept Internal Med Postgrad Sch Gastroenterol & Digest Endoscopy I-16126 Genoa Italy 

出 版 物：《ALIMENTARY PHARMACOLOGY & THERAPEUTICS》 (营养药理学与治疗学)

年 卷 期：2002年第16卷第4期

页      面：717-725页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学] 

主　　题：氨基比林/诊断应用 呼吸试验/方法 碳同位素/诊断应用 肝炎 丙型 慢性/并发症 肝炎 丙型 慢性/诊断 肝硬化/病因学 疾病严重程度指数 女(雌)性 人类 男(雄)性 中年人 

摘      要：Background: There are few data on the use of the C-13-aminopyrine breath test to evaluate the severity of disease in patients with hepatitis C virus-related chronic liver disease, although these patients represent one of the most important problems in clinical hepatology. Aims: To compare C-13-aminopyrine breath test results of patients with hepatitis C virus-related chronic hepatitis and Child-Pugh class A cirrhosis with those of normal subjects, and to evaluate different methods of expressing C-13-aminopyrine breath test results. Methods: Twenty-four patients with hepatitis C virus-related chronic hepatitis and 17 patients with Child-Pugh class A cirrhosis underwent C-13-aminopyrine breath test. Breath samples were collected every 30 min up to 2 h after C-13-aminopyrine administration. C-13-Aminopyrine breath test results were expressed as a percentage of the administered dose of C-13 recovered per hour (% dose/h) and the cumulative percentage of administered dose of C-13 recovered Over time (% dose cum). Nineteen healthy subjects served as controls. Patients with hepatitis C virus-related chronic hepatitis were divided into subgroups on the basis of histological staging and grading. Results: The C-13-aminopyrine breath test result (% dose/h) at 30 min was significantly different among the three subgroups of subjects (normal subjects, 11.5+/-3.5: chronic hepatitis patients. 8.1+/-4.1;cirrhosis patients, 5.0+/-3.1: P 2) fibrosis scores to be distinguished. The C-13-aminopyrine breath test results (% dose cum) at 30, 60 and 90 min a